Expression of LEPR in cancer - Summary - The Human Protein Atlas

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LEPR

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	LEPR
Gene description	Leptin receptor
Protein class	Cancer-related genes Candidate cardiovascular disease genes CD markers Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enhanced (K-562, RPTEC TERT1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	LEPR (HGNC Symbol)
Synonyms	CD295, OBR
Description	Leptin receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
Chromosome	1
Cytoband	p31.3
Chromosome location (bp)	65420652 - 65641559
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116678 (version 83.38)
Entrez gene	3953
UniProt	P48357 (UniProt - Evidence at protein level)
neXtProt	NX_P48357
Antibodypedia	LEPR antibodies

PROTEIN BROWSER

LEPR-001	LEPR-002	LEPR-003	LEPR-005	LEPR-201	LEPR-202	LEPR-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LEPR-001 ENSP00000330393 ENST00000349533	P48357 [Direct mapping] Leptin receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0008203 [cholesterol metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0043235 [receptor complex] GO:0045721 [negative regulation of gluconeogenesis] GO:0051346 [negative regulation of hydrolase activity] Show all	1165 aa 132.5 kDa	No	2
LEPR-002 ENSP00000360099 ENST00000371060	P48357 [Direct mapping] Leptin receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0043235 [receptor complex] Show all	896 aa 102.5 kDa	No	2
LEPR-003 ENSP00000360098 ENST00000371059	P48357 [Direct mapping] Leptin receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0043235 [receptor complex] Show all	958 aa 109.4 kDa	No	2
LEPR-005 ENSP00000360097 ENST00000371058	P48357 [Direct mapping] Leptin receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0043235 [receptor complex] Show all	906 aa 103.5 kDa	No	2
LEPR-201 ENSP00000340884 ENST00000344610	P48357 [Direct mapping] Leptin receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0043235 [receptor complex] Show all	906 aa 103.5 kDa	No	2
LEPR-202 ENSP00000384025 ENST00000406510	A2RRQ4 [Direct mapping] LEPR protein; Leptin receptor Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		232 aa 25.9 kDa	No	0
LEPR-203 ENSP00000483390 ENST00000616738	P48357 [Direct mapping] Leptin receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0043235 [receptor complex] Show all	896 aa 102.5 kDa	No	2

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The Human Protein Atlas

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