Fields »
ABOUT
HELP
BLOG
PDC

GENERAL INFORMATION

Gene name

 PDC

Gene description

 Phosducin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in photoreceptor cells in retina.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 1 antibody.
HPA062235
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA062235

GENE INFORMATION

Gene name

 PDC (HGNC Symbol)

Synonyms

 MEKA

Description

 Phosducin (HGNC Symbol)

Entrez gene summary

 This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q31.1

Chromosome location (bp)

 186443566 - 186461122

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116703 (version 83.38)

Entrez gene

 5132

UniProt

 P20941 (UniProt - Evidence at protein level)

neXtProt

 NX_P20941

Antibodypedia

 PDC antibodies

PROTEIN BROWSER
PDC-001
PDC-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDC-001
ENSP00000375855
ENST00000391997
P20941 [Direct mapping]
Phosducin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0004859 [phospholipase inhibitor activity]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007601 [visual perception]
GO:0007602 [phototransduction]
GO:0043086 [negative regulation of catalytic activity]
Show all
 246 aa
28.2 kDa 		No 0
PDC-002
ENSP00000422775
ENST00000497198
P20941 [Direct mapping]
Phosducin
A0A024R982 [Target identity:100%; Query identity:100%]
Phosducin, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0004859 [phospholipase inhibitor activity]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007601 [visual perception]
GO:0007602 [phototransduction]
GO:0043086 [negative regulation of catalytic activity]
Show all
 194 aa
22.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.