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UCHL5

GENERAL INFORMATION

Gene name

 UCHL5

Gene description

 Ubiquitin carboxyl-terminal hydrolase L5

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA005908
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005908

GENE INFORMATION

Gene name

 UCHL5 (HGNC Symbol)

Synonyms

 CGI-70, INO80R, UCH37

Description

 Ubiquitin carboxyl-terminal hydrolase L5 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q31.2

Chromosome location (bp)

 193012250 - 193060080

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116750 (version 83.38)

Entrez gene

 51377

UniProt

 Q9Y5K5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5K5

Antibodypedia

 UCHL5 antibodies

PROTEIN BROWSER
«
UCHL5-001
UCHL5-002
UCHL5-003
UCHL5-004
UCHL5-005
UCHL5-006
UCHL5-007
UCHL5-008
UCHL5-009
UCHL5-010
UCHL5-011
UCHL5-012
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UCHL5-001
ENSP00000356425
ENST00000367455
Q9Y5K5 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0004843 [ubiquitin-specific protease activity]
GO:0004866 [endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008242 [omega peptidase activity]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016579 [protein deubiquitination]
GO:0021670 [lateral ventricle development]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030901 [midbrain development]
GO:0031011 [Ino80 complex]
GO:0044822 [poly(A) RNA binding]
GO:0048853 [forebrain morphogenesis]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070628 [proteasome binding]
Show all
 329 aa
37.6 kDa 		No 0
UCHL5-002
ENSP00000356424
ENST00000367454
Q9Y5K5 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0004843 [ubiquitin-specific protease activity]
GO:0004866 [endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008242 [omega peptidase activity]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016579 [protein deubiquitination]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031011 [Ino80 complex]
GO:0044822 [poly(A) RNA binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070628 [proteasome binding]
Show all
 328 aa
37.5 kDa 		No 0
UCHL5-003
ENSP00000356419
ENST00000367449
Q9Y5K5 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0004843 [ubiquitin-specific protease activity]
GO:0004866 [endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008242 [omega peptidase activity]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016579 [protein deubiquitination]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031011 [Ino80 complex]
GO:0044822 [poly(A) RNA binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070628 [proteasome binding]
Show all
 316 aa
36.1 kDa 		No 0
UCHL5-004
ENSP00000356418
ENST00000367448
Q9Y5K5 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0004843 [ubiquitin-specific protease activity]
GO:0004866 [endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008242 [omega peptidase activity]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016579 [protein deubiquitination]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031011 [Ino80 complex]
GO:0044822 [poly(A) RNA binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070628 [proteasome binding]
Show all
 326 aa
37.4 kDa 		No 0
UCHL5-005
ENSP00000408720
ENST00000420791
H0Y6Y4 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
Show all
 218 aa
25.3 kDa 		No 0
UCHL5-006
ENSP00000356420
ENST00000367450
Q5LJA9 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008242 [omega peptidase activity]
Show all
 368 aa
41.7 kDa 		No 0
UCHL5-007
ENSP00000356421
ENST00000367451
Q5LJA5 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008242 [omega peptidase activity]
Show all
 355 aa
40.4 kDa 		No 0
UCHL5-008
ENSP00000392416
ENST00000416915
H0Y4K0 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
Show all
 99 aa
11.6 kDa 		No 0
UCHL5-009
ENSP00000402847
ENST00000449480
H0Y636 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
Show all
 115 aa
13.6 kDa 		No 0
UCHL5-010
ENSP00000412265
ENST00000417752
Q5LJB1 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 165 aa
18.3 kDa 		No 0
UCHL5-011
ENSP00000389563
ENST00000421683
Q5LJB0 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
Show all
 258 aa
29.1 kDa 		No 0
UCHL5-012
ENSP00000391153
ENST00000443327
H0Y4E0 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
Show all
 183 aa
21.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.