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BCAS2

GENERAL INFORMATION

Gene name

 BCAS2

Gene description

 Breast carcinoma amplified sequence 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and nucleolar expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA067881
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), prostate cancer (unfavourable), thyroid cancer (unfavourable), renal cancer (favourable) and ovarian cancer (favourable).
Liver cancer p<0.001
Prostate cancer p<0.001
Thyroid cancer p<0.001
Renal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA067881

GENE INFORMATION

Gene name

 BCAS2 (HGNC Symbol)

Synonyms

 DAM1, Snt309, SPF27

Description

 Breast carcinoma amplified sequence 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p13.2

Chromosome location (bp)

 114567557 - 114581639

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116752 (version 83.38)

Entrez gene

 10286

UniProt

 O75934 (UniProt - Evidence at protein level)

neXtProt

 NX_O75934

Antibodypedia

 BCAS2 antibodies

PROTEIN BROWSER
BCAS2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCAS2-001
ENSP00000358554
ENST00000369541
O75934 [Direct mapping]
Pre-mRNA-splicing factor SPF27
B2R7W3 [Target identity:100%; Query identity:100%]
Breast carcinoma amplified sequence 2; Breast carcinoma amplified sequence 2, isoform CRA_a; cDNA, FLJ93631, Homo sapiens breast carcinoma amplified sequence 2 (BCAS2), mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005662 [DNA replication factor A complex]
GO:0005681 [spliceosomal complex]
GO:0005730 [nucleolus]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0030054 [cell junction]
GO:0071011 [precatalytic spliceosome]
GO:0071012 [catalytic step 1 spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
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 225 aa
26.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.