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SRSF11

GENERAL INFORMATION

Gene name

 SRSF11

Gene description

 Serine/arginine-rich splicing factor 11

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA008762
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008762

GENE INFORMATION

Gene name

 SRSF11 (HGNC Symbol)

Synonyms

 NET2, p54, SFRS11

Description

 Serine/arginine-rich splicing factor 11 (HGNC Symbol)

Entrez gene summary

 This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]

Chromosome

 1

Cytoband

 p31.1

Chromosome location (bp)

 70205682 - 70253052

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116754 (version 83.38)

Entrez gene

 9295

UniProt

 Q05519 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05519

Antibodypedia

 SRSF11 antibodies

PROTEIN BROWSER
SRSF11-001
SRSF11-002
SRSF11-003
SRSF11-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRSF11-001
ENSP00000359988
ENST00000370950
Q05519 [Direct mapping]
Serine/arginine-rich splicing factor 11
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0031124 [mRNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
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 484 aa
53.5 kDa 		No 0
SRSF11-002
ENSP00000359989
ENST00000370951
Q05519 [Direct mapping]
Serine/arginine-rich splicing factor 11
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0031124 [mRNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
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 483 aa
53.4 kDa 		No 0
SRSF11-003
ENSP00000378568
ENST00000395136
Q5T760 [Direct mapping]
Serine/arginine-rich-splicing factor 11
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
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 389 aa
42.3 kDa 		No 0
SRSF11-004
ENSP00000359987
ENST00000370949
Q5T757 [Direct mapping]
Serine/arginine-rich-splicing factor 11
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
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 424 aa
48.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.