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CTH

GENERAL INFORMATION

Gene name

 CTH

Gene description

 Cystathionine gamma-lyase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (liver cancer, testis cancer)
HPA (cell line):Cell line enhanced (Karpas-707, SK-MEL-30)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 High cytoplasmic expression in liver and kidney, present in lower amounts in a few other tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA021591 , HPA023300
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (liver cancer, testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021591
HPA023300

GENE INFORMATION

Gene name

 CTH

Synonyms

Description

 Cystathionine gamma-lyase (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

Chromosome

 1

Cytoband

 p31.1

Chromosome location (bp)

 70411218 - 70439851

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116761 (version 83.38)

Entrez gene

 1491

UniProt

 P32929 (UniProt - Evidence at protein level)

neXtProt

 NX_P32929

Antibodypedia

 CTH antibodies

PROTEIN BROWSER
CTH-001
CTH-002
CTH-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTH-001
ENSP00000359976
ENST00000370938
P32929 [Direct mapping]
Cystathionine gamma-lyase
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Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0000098 [sulfur amino acid catabolic process]
GO:0004123 [cystathionine gamma-lyase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006534 [cysteine metabolic process]
GO:0016846 [carbon-sulfur lyase activity]
GO:0018272 [protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine]
GO:0019343 [cysteine biosynthetic process via cystathionine]
GO:0019344 [cysteine biosynthetic process]
GO:0019346 [transsulfuration]
GO:0030170 [pyridoxal phosphate binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0044281 [small molecule metabolic process]
GO:0044524 [protein sulfhydration]
GO:0044540 [L-cystine L-cysteine-lyase (deaminating)]
GO:0047982 [homocysteine desulfhydrase activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
GO:0070814 [hydrogen sulfide biosynthetic process]
GO:0080146 [L-cysteine desulfhydrase activity]
GO:2001234 [negative regulation of apoptotic signaling pathway]
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 405 aa
44.5 kDa 		No 0
CTH-002
ENSP00000311554
ENST00000346806
P32929 [Direct mapping]
Cystathionine gamma-lyase
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Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0000098 [sulfur amino acid catabolic process]
GO:0004123 [cystathionine gamma-lyase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006534 [cysteine metabolic process]
GO:0016846 [carbon-sulfur lyase activity]
GO:0018272 [protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine]
GO:0019343 [cysteine biosynthetic process via cystathionine]
GO:0019344 [cysteine biosynthetic process]
GO:0019346 [transsulfuration]
GO:0030170 [pyridoxal phosphate binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044524 [protein sulfhydration]
GO:0044540 [L-cystine L-cysteine-lyase (deaminating)]
GO:0047982 [homocysteine desulfhydrase activity]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
GO:0070814 [hydrogen sulfide biosynthetic process]
GO:0080146 [L-cysteine desulfhydrase activity]
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 361 aa
39.5 kDa 		No 0
CTH-201
ENSP00000413407
ENST00000411986
P32929 [Direct mapping]
Cystathionine gamma-lyase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0000098 [sulfur amino acid catabolic process]
GO:0004123 [cystathionine gamma-lyase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006534 [cysteine metabolic process]
GO:0016846 [carbon-sulfur lyase activity]
GO:0018272 [protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine]
GO:0019343 [cysteine biosynthetic process via cystathionine]
GO:0019344 [cysteine biosynthetic process]
GO:0019346 [transsulfuration]
GO:0030170 [pyridoxal phosphate binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044524 [protein sulfhydration]
GO:0044540 [L-cystine L-cysteine-lyase (deaminating)]
GO:0047982 [homocysteine desulfhydrase activity]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
GO:0070814 [hydrogen sulfide biosynthetic process]
GO:0080146 [L-cysteine desulfhydrase activity]
Show all
 373 aa
41.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.