Fields »
ABOUT
HELP
BLOG
AGMAT

GENERAL INFORMATION

Gene name

 AGMAT

Gene description

 Agmatine ureohydrolase (agmatinase)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (colorectal cancer, liver cancer, renal cancer, stomach cancer)
HPA (cell line):Cell line enhanced (CACO-2, Hep G2)
HPA (normal tissue):Tissue enhanced (kidney)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 High cytoplasmic expression in the GI-tract and renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA026443 , HPA028321
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (colorectal cancer, liver cancer, renal cancer, stomach cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA026443
HPA028321

GENE INFORMATION

Gene name

 AGMAT (HGNC Symbol)

Synonyms

 FLJ23384

Description

 Agmatine ureohydrolase (agmatinase) (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p36.21

Chromosome location (bp)

 15572353 - 15585110

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116771 (version 83.38)

Entrez gene

 79814

UniProt

 Q9BSE5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BSE5

Antibodypedia

 AGMAT antibodies

PROTEIN BROWSER
AGMAT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AGMAT-001
ENSP00000364986
ENST00000375826
Q9BSE5 [Direct mapping]
Agmatinase, mitochondrial
A0A024QZ78 [Target identity:100%; Query identity:100%]
Agmatine ureohydrolase (Agmatinase), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0006595 [polyamine metabolic process]
GO:0008295 [spermidine biosynthetic process]
GO:0008783 [agmatinase activity]
GO:0016813 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines]
GO:0033388 [putrescine biosynthetic process from arginine]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:0097055 [agmatine biosynthetic process]
Show all
 352 aa
37.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.