Tissue expression of TNNI3K - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TNNI3K
Gene description	TNNI3 interacting kinase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (heart muscle)
GTEx:	Tissue enhanced (cerebellum, heart muscle)
FANTOM5:	Tissue enriched (heart muscle)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (heart muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, heart muscle)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (heart muscle)

GENE INFORMATION
Gene name	TNNI3K (HGNC Symbol)
Synonyms	CARK
Description	TNNI3 interacting kinase (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012]
Chromosome	1
Cytoband	p31.1
Chromosome location (bp)	74235401 - 74544428
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116783 (version 83.38)
Entrez gene	51086
UniProt	Q59H18 (UniProt - Evidence at protein level)
neXtProt	NX_Q59H18
Antibodypedia	TNNI3K antibodies

PROTEIN BROWSER

TNNI3K-002	TNNI3K-003	TNNI3K-004	TNNI3K-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNNI3K-002 ENSP00000322251 ENST00000326637	Q59H18 [Direct mapping] Serine/threonine-protein kinase TNNI3K Show all	Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0002027 [regulation of heart rate] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0008022 [protein C-terminus binding] GO:0031013 [troponin I binding] GO:0046872 [metal ion binding] GO:0055117 [regulation of cardiac muscle contraction] GO:0086069 [bundle of His cell to Purkinje myocyte communication] GO:1903779 [regulation of cardiac conduction] Show all	835 aa 92.9 kDa	No	0
TNNI3K-003 ENSP00000431465 ENST00000526236	H0YCE9 [Direct mapping] Serine/threonine-protein kinase TNNI3K Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	150 aa 17 kDa	No	0
TNNI3K-004 ENSP00000434975 ENST00000534020	H0YE48 [Direct mapping] Serine/threonine-protein kinase TNNI3K Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	189 aa 21.9 kDa	No	0
TNNI3K-005 ENSP00000433550 ENST00000525480	H0YDG1 [Direct mapping] Serine/threonine-protein kinase TNNI3K Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	113 aa 12.7 kDa	No	0