Expression of PLEKHM2 in cancer - Summary - The Human Protein Atlas

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PLEKHM2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PLEKHM2
Gene description	Pleckstrin homology domain containing, family M (with RUN domain) member 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA032304
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA032304

GENE INFORMATION
Gene name	PLEKHM2 (HGNC Symbol)
Synonyms	KIAA0842
Description	Pleckstrin homology domain containing, family M (with RUN domain) member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p36.21
Chromosome location (bp)	15684332 - 15734769
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116786 (version 83.38)
Entrez gene	23207
UniProt	Q8IWE5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWE5
Antibodypedia	PLEKHM2 antibodies

PROTEIN BROWSER

PLEKHM2-001	PLEKHM2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLEKHM2-001 ENSP00000364956 ENST00000375799	Q8IWE5 [Direct mapping] Pleckstrin homology domain-containing family M member 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007030 [Golgi organization] GO:0019894 [kinesin binding] GO:0032880 [regulation of protein localization] Show all	1019 aa 112.8 kDa	No	0
PLEKHM2-002 ENSP00000364950 ENST00000375793	Q5VVD7 [Direct mapping] Pleckstrin homology domain-containing family M member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		999 aa 110.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.