Expression of CD58 in cancer - Summary - The Human Protein Atlas

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CD58

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	CD58
Gene description	CD58 molecule
Protein class	CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and pancreatic cancer (unfavourable).
Liver cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	CD58 (HGNC Symbol)
Synonyms	LFA3
Description	CD58 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Chromosome	1
Cytoband	p13.1
Chromosome location (bp)	116514535 - 116571039
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116815 (version 83.38)
Entrez gene	965
UniProt	P19256 (UniProt - Evidence at protein level)
neXtProt	NX_P19256
Antibodypedia	CD58 antibodies

PROTEIN BROWSER

CD58-001	CD58-002	CD58-004	CD58-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD58-001 ENSP00000358501 ENST00000369489	P19256 [Direct mapping] Lymphocyte function-associated antigen 3 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0031225 [anchored component of membrane] GO:0034113 [heterotypic cell-cell adhesion] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:0071346 [cellular response to interferon-gamma] GO:0071356 [cellular response to tumor necrosis factor] GO:2000484 [positive regulation of interleukin-8 secretion] Show all	250 aa 28.1 kDa	No	1
CD58-002 ENSP00000358499 ENST00000369487	B1AMW1 [Direct mapping] CD58 antigen, (Lymphocyte function-associated antigen 3), isoform CRA_c; Lymphocyte function-associated antigen 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	240 aa 27 kDa	No	1
CD58-004 ENSP00000409080 ENST00000457047	P19256 [Direct mapping] Lymphocyte function-associated antigen 3 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0031225 [anchored component of membrane] GO:0034113 [heterotypic cell-cell adhesion] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:0071346 [cellular response to interferon-gamma] GO:0071356 [cellular response to tumor necrosis factor] GO:2000484 [positive regulation of interleukin-8 secretion] Show all	248 aa 28 kDa	No	1
CD58-006 ENSP00000433648 ENST00000526981	H0YDI1 [Direct mapping] Lymphocyte function-associated antigen 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	131 aa 15.1 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.