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WARS2

GENERAL INFORMATION

Gene name

 WARS2

Gene description

 Tryptophanyl tRNA synthetase 2, mitochondrial

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mitochondrial expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA069692
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA069692

GENE INFORMATION

Gene name

 WARS2 (HGNC Symbol)

Synonyms

 TrpRS

Description

 Tryptophanyl tRNA synthetase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

 Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p12

Chromosome location (bp)

 119031216 - 119140671

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116874 (version 83.38)

Entrez gene

 10352

UniProt

 Q9UGM6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UGM6

Antibodypedia

 WARS2 antibodies

PROTEIN BROWSER
WARS2-001
WARS2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WARS2-001
ENSP00000235521
ENST00000235521
Q9UGM6 [Direct mapping]
Tryptophan--tRNA ligase, mitochondrial
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0001570 [vasculogenesis]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004830 [tryptophan-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006436 [tryptophanyl-tRNA aminoacylation]
GO:0010467 [gene expression]
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 360 aa
40.1 kDa 		No 0
WARS2-002
ENSP00000358434
ENST00000369426
Q9UGM6 [Direct mapping]
Tryptophan--tRNA ligase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004830 [tryptophan-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006436 [tryptophanyl-tRNA aminoacylation]
GO:0010467 [gene expression]
Show all
 220 aa
24.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.