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MTR

GENERAL INFORMATION

Gene name

 MTR

Gene description

 5-methyltetrahydrofolate-homocysteine methyltransferase

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MTR (HGNC Symbol)

Synonyms

 cblG

Description

 5-methyltetrahydrofolate-homocysteine methyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Chromosome

 1

Cytoband

 q43

Chromosome location (bp)

 236795281 - 236903981

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116984 (version 83.38)

Entrez gene

 4548

UniProt

 Q99707 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99707

Antibodypedia

 MTR antibodies

PROTEIN BROWSER
MTR-001
MTR-002
MTR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTR-001
ENSP00000355536
ENST00000366577
Q99707 [Direct mapping]
Methionine synthase
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007399 [nervous system development]
GO:0008270 [zinc ion binding]
GO:0008705 [methionine synthase activity]
GO:0008898 [S-adenosylmethionine-homocysteine S-methyltransferase activity]
GO:0009086 [methionine biosynthetic process]
GO:0009235 [cobalamin metabolic process]
GO:0031103 [axon regeneration]
GO:0031419 [cobalamin binding]
GO:0032259 [methylation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042558 [pteridine-containing compound metabolic process]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0048678 [response to axon injury]
GO:0071732 [cellular response to nitric oxide]
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 1265 aa
140.5 kDa 		No 0
MTR-002
ENSP00000355535
ENST00000366576
B1ANE3 [Direct mapping]
Methionine synthase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
GO:0008705 [methionine synthase activity]
GO:0008898 [S-adenosylmethionine-homocysteine S-methyltransferase activity]
GO:0009086 [methionine biosynthetic process]
GO:0031419 [cobalamin binding]
GO:0032259 [methylation]
GO:0042558 [pteridine-containing compound metabolic process]
GO:0044237 [cellular metabolic process]
GO:0046872 [metal ion binding]
Show all
 819 aa
91.8 kDa 		No 0
MTR-201
ENSP00000441845
ENST00000535889
Q99707 [Direct mapping]
Methionine synthase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007399 [nervous system development]
GO:0008270 [zinc ion binding]
GO:0008705 [methionine synthase activity]
GO:0008898 [S-adenosylmethionine-homocysteine S-methyltransferase activity]
GO:0009086 [methionine biosynthetic process]
GO:0009235 [cobalamin metabolic process]
GO:0031103 [axon regeneration]
GO:0031419 [cobalamin binding]
GO:0032259 [methylation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042558 [pteridine-containing compound metabolic process]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0048678 [response to axon injury]
GO:0071732 [cellular response to nitric oxide]
Show all
 1214 aa
134.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.