Expression of MYCL in cancer - Summary - The Human Protein Atlas

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MYCL

TISSUE

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CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	MYCL
Gene description	V-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
Protein class	Cancer-related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (U-266/70, U-266/84)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable).
Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	MYCL (HGNC Symbol)
Synonyms	bHLHe38, LMYC, MYCL1
Description	V-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	39895426 - 39902256
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116990 (version 83.38)
Entrez gene	4610
UniProt	P12524 (UniProt - Evidence at protein level)
neXtProt	NX_P12524
Antibodypedia	MYCL antibodies

PROTEIN BROWSER

MYCL-001	MYCL-002	MYCL-003	MYCL-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYCL-001 ENSP00000380494 ENST00000397332	P12524 [Direct mapping] Protein L-Myc Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0045607 [regulation of auditory receptor cell differentiation] GO:0046983 [protein dimerization activity] Show all	394 aa 43.2 kDa	No	0
MYCL-002 ENSP00000361902 ENST00000372815	P12524 [Direct mapping] Protein L-Myc Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	236 aa 24.7 kDa	No	0
MYCL-003 ENSP00000434375 ENST00000450953	E9PQS5 [Direct mapping] Protein L-Myc Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	100 aa 11.1 kDa	No	0
MYCL-004 ENSP00000361903 ENST00000372816	P12524 [Direct mapping] Protein L-Myc Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	364 aa 40.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.