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ACADM

GENERAL INFORMATION

Gene name

 ACADM

Gene description

 Acyl-CoA dehydrogenase, C-4 to C-12 straight chain

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA006198 , HPA026542
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006198
HPA026542

GENE INFORMATION

Gene name

 ACADM (HGNC Symbol)

Synonyms

 ACAD1, MCAD, MCADH

Description

 Acyl-CoA dehydrogenase, C-4 to C-12 straight chain (HGNC Symbol)

Entrez gene summary

 This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p31.1

Chromosome location (bp)

 75724347 - 75787575

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117054 (version 83.38)

Entrez gene

 34

UniProt

 P11310 (UniProt - Evidence at protein level)

neXtProt

 NX_P11310

Antibodypedia

 ACADM antibodies

PROTEIN BROWSER
ACADM-001
ACADM-002
ACADM-005
ACADM-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACADM-001
ENSP00000359878
ENST00000370841
P11310 [Direct mapping]
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0019254 [carnitine metabolic process, CoA-linked]
GO:0030424 [axon]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0042802 [identical protein binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045329 [carnitine biosynthetic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0051791 [medium-chain fatty acid metabolic process]
GO:0051793 [medium-chain fatty acid catabolic process]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070991 [medium-chain-acyl-CoA dehydrogenase activity]
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 421 aa
46.6 kDa 		No 0
ACADM-002
ENSP00000359871
ENST00000370834
Q5T4U5 [Direct mapping]
Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain, isoform CRA_a; Medium-chain-specific acyl-CoA dehydrogenase, mitochondrial
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   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0001889 [liver development]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0005739 [mitochondrion]
GO:0005978 [glycogen biosynthetic process]
GO:0006082 [organic acid metabolic process]
GO:0006111 [regulation of gluconeogenesis]
GO:0007507 [heart development]
GO:0007584 [response to nutrient]
GO:0008152 [metabolic process]
GO:0009409 [response to cold]
GO:0009437 [carnitine metabolic process]
GO:0009725 [response to hormone]
GO:0009791 [post-embryonic development]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0016853 [isomerase activity]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0042493 [response to drug]
GO:0042594 [response to starvation]
GO:0046688 [response to copper ion]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0051289 [protein homotetramerization]
GO:0051384 [response to glucocorticoid]
GO:0051793 [medium-chain fatty acid catabolic process]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055114 [oxidation-reduction process]
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 454 aa
50.3 kDa 		No 0
ACADM-005
ENSP00000409612
ENST00000420607
P11310 [Direct mapping]
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0019254 [carnitine metabolic process, CoA-linked]
GO:0030424 [axon]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0042802 [identical protein binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045329 [carnitine biosynthetic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0051791 [medium-chain fatty acid metabolic process]
GO:0051793 [medium-chain fatty acid catabolic process]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070991 [medium-chain-acyl-CoA dehydrogenase activity]
Show all
 425 aa
47 kDa 		No 0
ACADM-201
ENSP00000442324
ENST00000541113
B7Z9I1 [Direct mapping]
Medium-chain-specific acyl-CoA dehydrogenase, mitochondrial; cDNA, FLJ78845, highly similar to Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.99.3)
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 385 aa
42.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.