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MFAP2

GENERAL INFORMATION

Gene name

 MFAP2

Gene description

 Microfibrillar-associated protein 2

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, HUVEC TERT2, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (gallbladder)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in extracellular matrix in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
HPA007354
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA007354

GENE INFORMATION

Gene name

 MFAP2 (HGNC Symbol)

Synonyms

 MAGP, MAGP-1

Description

 Microfibrillar-associated protein 2 (HGNC Symbol)

Entrez gene summary

 Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 16974502 - 16980835

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117122 (version 83.38)

Entrez gene

 4237

UniProt

 P55001 (UniProt - Evidence at transcript level)

neXtProt

 NX_P55001

Antibodypedia

 MFAP2 antibodies

PROTEIN BROWSER
MFAP2-001
MFAP2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MFAP2-001
ENSP00000364685
ENST00000375535
P55001 [Direct mapping]
Microfibrillar-associated protein 2
A0A024RA94 [Target identity:100%; Query identity:100%]
Microfibrillar-associated protein 2, isoform CRA_d
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001527 [microfibril]
GO:0001968 [fibronectin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0030198 [extracellular matrix organization]
GO:0030220 [platelet formation]
GO:0048048 [embryonic eye morphogenesis]
GO:0048050 [post-embryonic eye morphogenesis]
GO:0070051 [fibrinogen binding]
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 183 aa
20.8 kDa 		Yes 0
MFAP2-003
ENSP00000364684
ENST00000375534
P55001 [Direct mapping]
Microfibrillar-associated protein 2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001527 [microfibril]
GO:0005576 [extracellular region]
GO:0030198 [extracellular matrix organization]
GO:0048048 [embryonic eye morphogenesis]
GO:0048050 [post-embryonic eye morphogenesis]
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 182 aa
20.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.