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RPF1

GENERAL INFORMATION

Gene name

 RPF1

Gene description

 Ribosome production factor 1 homolog

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 High nucleolar expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA024642
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024642

GENE INFORMATION

Gene name

 RPF1 (HGNC Symbol)

Synonyms

 BXDC5

Description

 Ribosome production factor 1 homolog (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p22.3

Chromosome location (bp)

 84479259 - 84497790

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117133 (version 83.38)

Entrez gene

 80135

UniProt

 Q9H9Y2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H9Y2

Antibodypedia

 RPF1 antibodies

PROTEIN BROWSER
RPF1-001
RPF1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPF1-001
ENSP00000359688
ENST00000370654
Q9H9Y2 [Direct mapping]
Ribosome production factor 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000027 [ribosomal large subunit assembly]
GO:0000460 [maturation of 5.8S rRNA]
GO:0000470 [maturation of LSU-rRNA]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0030687 [preribosome, large subunit precursor]
GO:0042134 [rRNA primary transcript binding]
GO:0044822 [poly(A) RNA binding]
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 349 aa
40.1 kDa 		No 0
RPF1-002
ENSP00000359690
ENST00000370656
X6R7Q1 [Direct mapping]
Ribosome production factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000027 [ribosomal large subunit assembly]
GO:0000460 [maturation of 5.8S rRNA]
GO:0000470 [maturation of LSU-rRNA]
GO:0030687 [preribosome, large subunit precursor]
GO:0042134 [rRNA primary transcript binding]
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 129 aa
14.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.