Tissue expression of IGSF21 - Summary - The Human Protein Atlas

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IGSF21

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	IGSF21
Gene description	Immunoglobin superfamily, member 21
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, spleen)
GTEx:	Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5:	Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues including a subset of neurons in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA044535
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION
Gene name	IGSF21 (HGNC Symbol)
Synonyms	MGC15730, RP11-121A23.1
Description	Immunoglobin superfamily, member 21 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Sep 2011]
Chromosome	1
Cytoband	p36.13
Chromosome location (bp)	18107746 - 18378483
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117154 (version 83.38)
Entrez gene	84966
UniProt	Q96ID5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96ID5
Antibodypedia	IGSF21 antibodies

PROTEIN BROWSER

IGSF21-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGSF21-001 ENSP00000251296 ENST00000251296	Q96ID5 [Direct mapping] Immunoglobulin superfamily member 21 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	467 aa 51.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.