Fields »
ABOUT
HELP
BLOG
PLA2G2D

GENERAL INFORMATION

Gene name

 PLA2G2D

Gene description

 Phospholipase A2, group IID

Protein class

 Enzymes
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Cell line enriched (RPMI-8226)
HPA (normal tissue):Tissue enhanced (lymph node, tonsil)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable), breast cancer (favourable) and endometrial cancer (favourable).
Cervical cancer p<0.001
Breast cancer p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PLA2G2D (HGNC Symbol)

Synonyms

 sPLA2S

Description

 Phospholipase A2, group IID (HGNC Symbol)

Entrez gene summary

 This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

Chromosome

 1

Cytoband

 p36.12

Chromosome location (bp)

 20111939 - 20119566

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117215 (version 83.38)

Entrez gene

 26279

UniProt

 Q9UNK4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNK4

Antibodypedia

 PLA2G2D antibodies

PROTEIN BROWSER
PLA2G2D-001
PLA2G2D-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLA2G2D-001
ENSP00000364246
ENST00000375105
Q9UNK4 [Direct mapping]
Group IID secretory phospholipase A2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Show all
GO:0002361 [CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation]
GO:0004623 [phospholipase A2 activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0006954 [inflammatory response]
GO:0008201 [heparin binding]
GO:0016042 [lipid catabolic process]
GO:0036148 [phosphatidylglycerol acyl-chain remodeling]
GO:0036149 [phosphatidylinositol acyl-chain remodeling]
GO:0036150 [phosphatidylserine acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0042130 [negative regulation of T cell proliferation]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0050868 [negative regulation of T cell activation]
Show all
 145 aa
16.5 kDa 		Yes 0
PLA2G2D-201
ENSP00000482871
ENST00000617227
A0A087WZT4 [Direct mapping]
Phospholipase A(2)
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Show all
GO:0004623 [phospholipase A2 activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0016042 [lipid catabolic process]
Show all
 62 aa
6.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.