Fields »
ABOUT
HELP
BLOG
ATP6V0B

GENERAL INFORMATION

Gene name

 ATP6V0B

Gene description

 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), pancreatic cancer (favourable), liver cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Liver cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ATP6V0B (HGNC Symbol)

Synonyms

 ATP6F, HATPL, VMA16

Description

 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (HGNC Symbol)

Entrez gene summary

 This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

 1

Cytoband

 p34.1

Chromosome location (bp)

 43974487 - 43978295

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000117410 (version 83.38)

Entrez gene

 533

UniProt

 Q99437 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q99437

Antibodypedia

 ATP6V0B antibodies

PROTEIN BROWSER
ATP6V0B-001
ATP6V0B-004
ATP6V0B-006
ATP6V0B-011
ATP6V0B-012
ATP6V0B-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP6V0B-001
ENSP00000431605
ENST00000472174
Q99437 [Direct mapping]
V-type proton ATPase 21 kDa proteolipid subunit
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain]
GO:0005215 [transporter activity]
GO:0006879 [cellular iron ion homeostasis]
GO:0007035 [vacuolar acidification]
GO:0008286 [insulin receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0055085 [transmembrane transport]
GO:0090382 [phagosome maturation]
Show all
 205 aa
21.4 kDa 		No 5
ATP6V0B-004
ENSP00000236067
ENST00000236067
Q99437 [Direct mapping]
V-type proton ATPase 21 kDa proteolipid subunit
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain]
GO:0005215 [transporter activity]
GO:0006879 [cellular iron ion homeostasis]
GO:0007035 [vacuolar acidification]
GO:0008286 [insulin receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0055085 [transmembrane transport]
GO:0090382 [phagosome maturation]
Show all
 158 aa
16.2 kDa 		No 3
ATP6V0B-006
ENSP00000432754
ENST00000471859
E9PNU0 [Direct mapping]
V-type proton ATPase 21 kDa proteolipid subunit
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
Show all
 252 aa
26.1 kDa 		Yes 4
ATP6V0B-011
ENSP00000434094
ENST00000498664
Q99437 [Direct mapping]
V-type proton ATPase 21 kDa proteolipid subunit
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain]
GO:0005215 [transporter activity]
GO:0006879 [cellular iron ion homeostasis]
GO:0007035 [vacuolar acidification]
GO:0008286 [insulin receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0055085 [transmembrane transport]
GO:0090382 [phagosome maturation]
Show all
 158 aa
16.2 kDa 		No 3
ATP6V0B-012
ENSP00000434729
ENST00000532642
E9PNL3 [Direct mapping]
V-type proton ATPase 21 kDa proteolipid subunit
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0005768 [endosome]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
Show all
 261 aa
27.7 kDa 		No 5
ATP6V0B-013
ENSP00000432994
ENST00000472505
E9PMR1 [Direct mapping]
V-type proton ATPase 21 kDa proteolipid subunit
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
Show all
 86 aa
9 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.