Tissue expression of PTCH2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PTCH2
Gene description	Patched 2
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (parathyroid gland)
GTEx:	Tissue enhanced (testis)
FANTOM5:	Tissue enhanced (testis)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION
Gene name	PTCH2
Synonyms
Description	Patched 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]
Chromosome	1
Cytoband	p34.1
Chromosome location (bp)	44819844 - 44843063
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000117425 (version 83.38)
Entrez gene	8643
UniProt	Q9Y6C5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y6C5
Antibodypedia	PTCH2 antibodies

PROTEIN BROWSER

PTCH2-001	PTCH2-002	PTCH2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTCH2-001 ENSP00000361266 ENST00000372192	Q9Y6C5 [Direct mapping] Protein patched homolog 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0001709 [cell fate determination] GO:0005119 [smoothened binding] GO:0007165 [signal transduction] GO:0008158 [hedgehog receptor activity] GO:0008544 [epidermis development] GO:0009957 [epidermal cell fate specification] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042633 [hair cycle] GO:0043588 [skin development] GO:0045606 [positive regulation of epidermal cell differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0097108 [hedgehog family protein binding] Show all	1203 aa 130.5 kDa	No	>9
PTCH2-002 ENSP00000413169 ENST00000438067	H0Y7J2 [Direct mapping] Protein patched homolog 2 Show all	MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	88 aa 9.7 kDa	No	0
PTCH2-201 ENSP00000389703 ENST00000447098	Q9Y6C5 [Direct mapping] Protein patched homolog 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0005119 [smoothened binding] GO:0007165 [signal transduction] GO:0008158 [hedgehog receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0097108 [hedgehog family protein binding] Show all	1146 aa 124.9 kDa	No	>9