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AKR1A1

GENERAL INFORMATION

Gene name

 AKR1A1

Gene description

 Aldo-keto reductase family 1, member A1 (aldehyde reductase)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and nuclear expression in renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 4 antibodies.
HPA017919 , HPA019649 , HPA027734 , CAB006246
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable) and endometrial cancer (favourable).
Cervical cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017919
HPA019649
HPA027734
CAB006246

GENE INFORMATION

Gene name

 AKR1A1 (HGNC Symbol)

Synonyms

 ALR, DD3

Description

 Aldo-keto reductase family 1, member A1 (aldehyde reductase) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]

Chromosome

 1

Cytoband

 p34.1

Chromosome location (bp)

 45550543 - 45570049

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117448 (version 83.38)

Entrez gene

 10327

UniProt

 P14550 (UniProt - Evidence at protein level)

neXtProt

 NX_P14550

Antibodypedia

 AKR1A1 antibodies

PROTEIN BROWSER
AKR1A1-001
AKR1A1-002
AKR1A1-004
AKR1A1-007
AKR1A1-011
AKR1A1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKR1A1-001
ENSP00000361140
ENST00000372070
P14550 [Direct mapping]
Alcohol dehydrogenase [NADP(+)]
V9HWI0 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 6; Epididymis secretory sperm binding protein Li 165mP
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009055 [electron carrier activity]
GO:0016324 [apical plasma membrane]
GO:0016491 [oxidoreductase activity]
GO:0019640 [glucuronate catabolic process to xylulose 5-phosphate]
GO:0019853 [L-ascorbic acid biosynthetic process]
GO:0042840 [D-glucuronate catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046185 [aldehyde catabolic process]
GO:0047939 [L-glucuronate reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1901687 [glutathione derivative biosynthetic process]
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 325 aa
36.6 kDa 		No 0
AKR1A1-002
ENSP00000312606
ENST00000351829
P14550 [Direct mapping]
Alcohol dehydrogenase [NADP(+)]
V9HWI0 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 6; Epididymis secretory sperm binding protein Li 165mP
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009055 [electron carrier activity]
GO:0016491 [oxidoreductase activity]
GO:0019640 [glucuronate catabolic process to xylulose 5-phosphate]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 325 aa
36.6 kDa 		No 0
AKR1A1-004
ENSP00000398414
ENST00000434299
Q5T621 [Direct mapping]
Alcohol dehydrogenase [NADP(+)]
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 147 aa
16.5 kDa 		No 0
AKR1A1-007
ENSP00000476713
ENST00000471651
V9GYG2 [Direct mapping]
Alcohol dehydrogenase [NADP(+)]
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 119 aa
13.3 kDa 		No 0
AKR1A1-011
ENSP00000476978
ENST00000481885
V9GYP9 [Direct mapping]
Alcohol dehydrogenase [NADP(+)]
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 140 aa
15.6 kDa 		No 0
AKR1A1-201
ENSP00000480713
ENST00000621846
P14550 [Direct mapping]
Alcohol dehydrogenase [NADP(+)]
V9HWI0 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 6; Epididymis secretory sperm binding protein Li 165mP
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009055 [electron carrier activity]
GO:0016491 [oxidoreductase activity]
GO:0019640 [glucuronate catabolic process to xylulose 5-phosphate]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 325 aa
36.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.