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PRDX1

GENERAL INFORMATION

Gene name

 PRDX1

Gene description

 Peroxiredoxin 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA007730 , CAB004682
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and urothelial cancer (unfavourable).
Liver cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007730
CAB004682

GENE INFORMATION

Gene name

 PRDX1 (HGNC Symbol)

Synonyms

 NKEFA, PAGA

Description

 Peroxiredoxin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

Chromosome

 1

Cytoband

 p34.1

Chromosome location (bp)

 45511036 - 45523047

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117450 (version 83.38)

Entrez gene

 5052

UniProt

 Q06830 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06830

Antibodypedia

 PRDX1 antibodies

PROTEIN BROWSER
PRDX1-001
PRDX1-002
PRDX1-003
PRDX1-004
PRDX1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRDX1-001
ENSP00000361152
ENST00000319248
Q06830 [Direct mapping]
Peroxiredoxin-1
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001501 [skeletal system development]
GO:0001895 [retina homeostasis]
GO:0004601 [peroxidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008379 [thioredoxin peroxidase activity]
GO:0010467 [gene expression]
GO:0016209 [antioxidant activity]
GO:0016491 [oxidoreductase activity]
GO:0042470 [melanosome]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0051920 [peroxiredoxin activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 199 aa
22.1 kDa 		No 0
PRDX1-002
ENSP00000407034
ENST00000447184
A0A0A0MSI0 [Direct mapping]
Peroxiredoxin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016209 [antioxidant activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 171 aa
19 kDa 		No 0
PRDX1-003
ENSP00000361150
ENST00000372079
A0A0A0MRQ5 [Direct mapping]
Peroxiredoxin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0051920 [peroxiredoxin activity]
GO:0055114 [oxidation-reduction process]
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 97 aa
10.7 kDa 		No 0
PRDX1-004
ENSP00000389047
ENST00000424390
A0A0A0MSI0 [Direct mapping]
Peroxiredoxin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016209 [antioxidant activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 171 aa
19 kDa 		No 0
PRDX1-201
ENSP00000262746
ENST00000262746
Q06830 [Direct mapping]
Peroxiredoxin-1
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001501 [skeletal system development]
GO:0001895 [retina homeostasis]
GO:0004601 [peroxidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006979 [response to oxidative stress]
GO:0008283 [cell proliferation]
GO:0008379 [thioredoxin peroxidase activity]
GO:0010467 [gene expression]
GO:0016209 [antioxidant activity]
GO:0016491 [oxidoreductase activity]
GO:0019430 [removal of superoxide radicals]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0034101 [erythrocyte homeostasis]
GO:0042267 [natural killer cell mediated cytotoxicity]
GO:0042345 [regulation of NF-kappaB import into nucleus]
GO:0042470 [melanosome]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0042802 [identical protein binding]
GO:0043209 [myelin sheath]
GO:0044822 [poly(A) RNA binding]
GO:0051920 [peroxiredoxin activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 199 aa
22.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.