Expression of FAAH in cancer - Summary - The Human Protein Atlas

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FAAH

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAAH
Gene description	Fatty acid amide hydrolase
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BEWO, RT4)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA007425
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (favourable), renal cancer (favourable) and endometrial cancer (favourable).
Stomach cancer p<0.001 Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007425

GENE INFORMATION
Gene name	FAAH (HGNC Symbol)
Synonyms	FAAH-1
Description	Fatty acid amide hydrolase (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p33
Chromosome location (bp)	46394265 - 46413848
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117480 (version 83.38)
Entrez gene	2166
UniProt	O00519 (UniProt - Evidence at protein level)
neXtProt	NX_O00519
Antibodypedia	FAAH antibodies

PROTEIN BROWSER

FAAH-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAAH-001 ENSP00000243167 ENST00000243167	O00519 [Direct mapping] Fatty-acid amide hydrolase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005856 [cytoskeleton] GO:0009062 [fatty acid catabolic process] GO:0016021 [integral component of membrane] GO:0016884 [carbon-nitrogen ligase activity, with glutamine as amido-N-donor] GO:0017064 [fatty acid amide hydrolase activity] GO:0019369 [arachidonic acid metabolic process] GO:0031090 [organelle membrane] GO:0044281 [small molecule metabolic process] GO:0047372 [acylglycerol lipase activity] Show all	579 aa 63.1 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.