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PRDX6

GENERAL INFORMATION

Gene name

 PRDX6

Gene description

 Peroxiredoxin 6

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA006983 , CAB008663
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PRDX6 (HGNC Symbol)

Synonyms

 1-Cys, aiPLA2, AOP2, KIAA0106, MGC46173, NSGPx, p29, PRX

Description

 Peroxiredoxin 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q25.1

Chromosome location (bp)

 173477266 - 173488807

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117592 (version 83.38)

Entrez gene

 9588

UniProt

 P30041 (UniProt - Evidence at protein level)

neXtProt

 NX_P30041

Antibodypedia

 PRDX6 antibodies

PROTEIN BROWSER
PRDX6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRDX6-001
ENSP00000342026
ENST00000340385
P30041 [Direct mapping]
Peroxiredoxin-6
V9HWC7 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 128m; Peroxiredoxin 6, isoform CRA_a
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004602 [glutathione peroxidase activity]
GO:0004623 [phospholipase A2 activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0006979 [response to oxidative stress]
GO:0009395 [phospholipid catabolic process]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016209 [antioxidant activity]
GO:0016491 [oxidoreductase activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0051920 [peroxiredoxin activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 224 aa
25 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.