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HSD11B1

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GENERAL INFORMATION

Gene name

 HSD11B1

Gene description

 Hydroxysteroid (11-beta) dehydrogenase 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (ASC TERT1, Karpas-707, BJ hTERT+, THP-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1, Karpas-707, BJ hTERT+, THP-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 HSD11B1 (HGNC Symbol)

Synonyms

 HSD11, HSD11B, SDR26C1

Description

 Hydroxysteroid (11-beta) dehydrogenase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]

Chromosome

 1

Cytoband

 q32.2

Chromosome location (bp)

 209686178 - 209734950

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117594 (version 83.38)

Entrez gene

 3290

UniProt

 P28845 (UniProt - Evidence at protein level)

neXtProt

 NX_P28845

Antibodypedia

 HSD11B1 antibodies

PROTEIN BROWSER
HSD11B1-001
HSD11B1-002
HSD11B1-003
HSD11B1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSD11B1-001
ENSP00000355994
ENST00000367027
P28845 [Direct mapping]
Corticosteroid 11-beta-dehydrogenase isozyme 1
X5D2L1 [Target identity:100%; Query identity:100%]
Hydroxysteroid 11-beta dehydrogenase 1 isoform A
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0006704 [glucocorticoid biosynthetic process]
GO:0008152 [metabolic process]
GO:0008202 [steroid metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070524 [11-beta-hydroxysteroid dehydrogenase (NADP+) activity]
Show all
 292 aa
32.4 kDa 		No 0
HSD11B1-002
ENSP00000261465
ENST00000261465
A0A0A0MQV1 [Direct mapping]
Corticosteroid 11-beta-dehydrogenase isozyme 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 279 aa
30.8 kDa 		No 0
HSD11B1-003
ENSP00000478430
ENST00000615289
A0A087WU76 [Direct mapping]
Corticosteroid 11-beta-dehydrogenase isozyme 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 182 aa
20 kDa 		No 0
HSD11B1-201
ENSP00000355995
ENST00000367028
P28845 [Direct mapping]
Corticosteroid 11-beta-dehydrogenase isozyme 1
X5D2L1 [Target identity:100%; Query identity:100%]
Hydroxysteroid 11-beta dehydrogenase 1 isoform A
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003845 [11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006704 [glucocorticoid biosynthetic process]
GO:0008152 [metabolic process]
GO:0008202 [steroid metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0030324 [lung development]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070524 [11-beta-hydroxysteroid dehydrogenase (NADP+) activity]
Show all
 292 aa
32.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.