Expression of SERPINC1 in cancer - Summary

GENERAL INFORMATION
Gene name	SERPINC1
Gene description	Serpin peptidase inhibitor, clade C (antithrombin), member 1
Protein class	Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct positivity in plasma. Also expressed at lower levels in the cytoplasm of several cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 3 antibodies. HPA001816 , HPA024007 , CAB016790
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA001816	HPA024007	CAB016790

GENE INFORMATION
Gene name	SERPINC1 (HGNC Symbol)
Synonyms	AT3, ATIII, MGC22579
Description	Serpin peptidase inhibitor, clade C (antithrombin), member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]
Chromosome	1
Cytoband	q25.1
Chromosome location (bp)	173903804 - 173917378
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117601 (version 83.38)
Entrez gene	462
UniProt	P01008 (UniProt - Evidence at protein level)
neXtProt	NX_P01008
Antibodypedia	SERPINC1 antibodies

PROTEIN BROWSER

SERPINC1-001	SERPINC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINC1-001 ENSP00000356671 ENST00000367698	P01008 [Direct mapping] Antithrombin-III A0A024R944 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade C (Antithrombin), member 1, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0007584 [response to nutrient] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0050728 [negative regulation of inflammatory response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] GO:2000266 [regulation of blood coagulation, intrinsic pathway] Show all	464 aa 52.6 kDa	Yes	0
SERPINC1-201 ENSP00000478688 ENST00000617423	Q8TCE1 [Direct mapping] Antithrombin-III; SERPINC1 protein Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0008201 [heparin binding] GO:0010951 [negative regulation of endopeptidase activity] GO:2000266 [regulation of blood coagulation, intrinsic pathway] Show all	259 aa 29.1 kDa	Yes	0