Expression of RCOR3 in cancer - Summary - The Human Protein Atlas

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RCOR3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RCOR3
Gene description	REST corepressor 3
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA007413
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (favourable) and lung cancer (favourable).
Glioma p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007413

GENE INFORMATION
Gene name	RCOR3 (HGNC Symbol)
Synonyms	FLJ10876
Description	REST corepressor 3 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband
Chromosome location (bp)	211258377 - 211316385
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117625 (version 83.38)
Entrez gene	55758
UniProt	Q9P2K3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P2K3
Antibodypedia	RCOR3 antibodies

PROTEIN BROWSER

RCOR3-001	RCOR3-002	RCOR3-006	RCOR3-007	RCOR3-011	RCOR3-012	RCOR3-014	RCOR3-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RCOR3-001 ENSP00000355972 ENST00000367005	Q9P2K3 [Direct mapping] REST corepressor 3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	495 aa 55.6 kDa	No	0
RCOR3-002 ENSP00000355973 ENST00000367006	Q9P2K3 [Direct mapping] REST corepressor 3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	436 aa 47.8 kDa	No	0
RCOR3-006 ENSP00000413929 ENST00000419091	Q9P2K3 [Direct mapping] REST corepressor 3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0019899 [enzyme binding] Show all	553 aa 61.2 kDa	No	0
RCOR3-007 ENSP00000398558 ENST00000452621	Q9P2K3 [Direct mapping] REST corepressor 3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	449 aa 50.4 kDa	No	0
RCOR3-011 ENSP00000436057 ENST00000534478	E9PR63 [Direct mapping] REST corepressor 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 9.8 kDa	No	0
RCOR3-012 ENSP00000436838 ENST00000533469	E9PQE5 [Direct mapping] REST corepressor 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	149 aa 17.4 kDa	No	0
RCOR3-014 ENSP00000433441 ENST00000534460	H0YDD7 [Direct mapping] REST corepressor 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		143 aa 15.9 kDa	No	0
RCOR3-016 ENSP00000437048 ENST00000529763	H0YF22 [Direct mapping] REST corepressor 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	240 aa 26.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.