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PPP1R8

GENERAL INFORMATION

Gene name

 PPP1R8

Gene description

 Protein phosphatase 1, regulatory subunit 8

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA027406 , HPA027417 , HPA027452
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027406
HPA027417
HPA027452

GENE INFORMATION

Gene name

 PPP1R8 (HGNC Symbol)

Synonyms

 ard-1, ARD1, NIPP-1, NIPP1, PRO2047

Description

 Protein phosphatase 1, regulatory subunit 8 (HGNC Symbol)

Entrez gene summary

 This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p35.3

Chromosome location (bp)

 27830778 - 27851676

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117751 (version 83.38)

Entrez gene

 5511

UniProt

 Q12972 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12972

Antibodypedia

 PPP1R8 antibodies

PROTEIN BROWSER
PPP1R8-001
PPP1R8-002
PPP1R8-003
PPP1R8-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP1R8-001
ENSP00000311677
ENST00000311772
Q12972 [Direct mapping]
Nuclear inhibitor of protein phosphatase 1 Activator of RNA decay
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0004519 [endonuclease activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006401 [RNA catabolic process]
GO:0008283 [cell proliferation]
GO:0008380 [RNA splicing]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0008995 [ribonuclease E activity]
GO:0016607 [nuclear speck]
GO:0043086 [negative regulation of catalytic activity]
GO:0050790 [regulation of catalytic activity]
GO:0090501 [RNA phosphodiester bond hydrolysis]
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 351 aa
38.5 kDa 		No 0
PPP1R8-002
ENSP00000363042
ENST00000373931
Q12972 [Direct mapping]
Nuclear inhibitor of protein phosphatase 1 Activator of RNA decay
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0004519 [endonuclease activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006401 [RNA catabolic process]
GO:0008380 [RNA splicing]
GO:0008995 [ribonuclease E activity]
GO:0016607 [nuclear speck]
GO:0043086 [negative regulation of catalytic activity]
GO:0090501 [RNA phosphodiester bond hydrolysis]
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 209 aa
22.7 kDa 		No 0
PPP1R8-003
ENSP00000236412
ENST00000236412
Q12972 [Direct mapping]
Nuclear inhibitor of protein phosphatase 1 Activator of RNA decay
Q6ICT4 [Target identity:100%; Query identity:100%]
PPP1R8 protein; Protein phosphatase 1, regulatory (Inhibitor) subunit 8, isoform CRA_f; cDNA FLJ60722, highly similar to Nuclear inhibitor of protein phosphatase 1; cDNA, FLJ94432, Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit8 (PPP1R8), transcript variant 3, mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0004519 [endonuclease activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006401 [RNA catabolic process]
GO:0008380 [RNA splicing]
GO:0008995 [ribonuclease E activity]
GO:0016607 [nuclear speck]
GO:0043086 [negative regulation of catalytic activity]
GO:0090501 [RNA phosphodiester bond hydrolysis]
Show all
 127 aa
13.3 kDa 		No 0
PPP1R8-005
ENSP00000410206
ENST00000431586
A0A0A0MT09 [Direct mapping]
Nuclear inhibitor of protein phosphatase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 205 aa
22.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.