Expression of MARC2 in cancer - Summary

GENERAL INFORMATION
Gene name	MARC2
Gene description	Mitochondrial amidoxime reducing component 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (T-47d)
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues, high expression in parathyroid gland, liver, small intestine and renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA015085 , HPA017572
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable) and renal cancer (favourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA015085	HPA017572

GENE INFORMATION
Gene name	MARC2 (HGNC Symbol)
Synonyms	FLJ20605, MOSC2
Description	Mitochondrial amidoxime reducing component 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
Chromosome	1
Cytoband	q41
Chromosome location (bp)	220748225 - 220784815
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117791 (version 83.38)
Entrez gene	54996
UniProt	Q969Z3 (UniProt - Evidence at protein level)
neXtProt	NX_Q969Z3
Antibodypedia	MARC2 antibodies

PROTEIN BROWSER

MARC2-001	MARC2-002	MARC2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARC2-001 ENSP00000355880 ENST00000366913	Q969Z3 [Direct mapping] Mitochondrial amidoxime reducing component 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005743 [mitochondrial inner membrane] GO:0005777 [peroxisome] GO:0008940 [nitrate reductase activity] GO:0030151 [molybdenum ion binding] GO:0030170 [pyridoxal phosphate binding] GO:0042126 [nitrate metabolic process] GO:0043546 [molybdopterin cofactor binding] GO:0051410 [detoxification of nitrogen compound] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	335 aa 38 kDa	No	1
MARC2-002 ENSP00000352266 ENST00000359316	Q969Z3 [Direct mapping] Mitochondrial amidoxime reducing component 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005777 [peroxisome] GO:0008940 [nitrate reductase activity] GO:0030151 [molybdenum ion binding] GO:0030170 [pyridoxal phosphate binding] GO:0042126 [nitrate metabolic process] GO:0043546 [molybdopterin cofactor binding] GO:0051410 [detoxification of nitrogen compound] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	257 aa 29.1 kDa	No	1
MARC2-006 ENSP00000416442 ENST00000425560	X1WI34 [Direct mapping] Mitochondrial amidoxime reducing component 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0030151 [molybdenum ion binding] GO:0030170 [pyridoxal phosphate binding] Show all	172 aa 19.8 kDa	No	0