Cell atlas - TXNDC12 - The Human Protein Atlas

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TXNDC12

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	TXNDC12
Gene description	Thioredoxin domain containing 12 (endoplasmic reticulum)
Protein class	Enzymes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	TXNDC12 (HGNC Symbol)
Synonyms	AGR1, ERP18, ERP19, hAG-1, PDIA16, TLP19
Description	Thioredoxin domain containing 12 (endoplasmic reticulum) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
Chromosome	1
Cytoband	p32.3
Chromosome location (bp)	52020131 - 52056171
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117862 (version 83.38)
Entrez gene	51060
UniProt	O95881 (UniProt - Evidence at protein level)
neXtProt	NX_O95881
Antibodypedia	TXNDC12 antibodies

PROTEIN BROWSER

TXNDC12-001	TXNDC12-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TXNDC12-001 ENSP00000360688 ENST00000371626	O95881 [Direct mapping] Thioredoxin domain-containing protein 12 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0015037 [peptide disulfide oxidoreductase activity] GO:0019153 [protein-disulfide reductase (glutathione) activity] GO:0045454 [cell redox homeostasis] GO:0055114 [oxidation-reduction process] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] Show all	172 aa 19.2 kDa	Yes	0
TXNDC12-005 ENSP00000476401 ENST00000610127	V9GY50 [Direct mapping] Thioredoxin domain-containing protein 12 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		55 aa 6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.