Expression of ESYT2 in cancer - Summary - The Human Protein Atlas

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ESYT2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ESYT2
Gene description	Extended synaptotagmin-like protein 2
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA002132
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable) and pancreatic cancer (unfavourable).
Urothelial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA002132

GENE INFORMATION
Gene name	ESYT2 (HGNC Symbol)
Synonyms	CHR2SYT, FAM62B, KIAA1228
Description	Extended synaptotagmin-like protein 2 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q36.3
Chromosome location (bp)	158730995 - 158830253
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117868 (version 83.38)
Entrez gene	57488
UniProt	A0FGR8 (UniProt - Evidence at protein level)
neXtProt	NX_A0FGR8
Antibodypedia	ESYT2 antibodies

PROTEIN BROWSER

ESYT2-001	ESYT2-004	ESYT2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ESYT2-001 ENSP00000251527 ENST00000251527	A0FGR8 [Direct mapping] Extended synaptotagmin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005783 [endoplasmic reticulum] GO:0005887 [integral component of plasma membrane] GO:0006869 [lipid transport] GO:0006897 [endocytosis] GO:0008429 [phosphatidylethanolamine binding] GO:0016020 [membrane] GO:0031210 [phosphatidylcholine binding] GO:0031227 [intrinsic component of endoplasmic reticulum membrane] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0035091 [phosphatidylinositol binding] GO:0042802 [identical protein binding] GO:0044232 [organelle membrane contact site] Show all	893 aa 98.9 kDa	No	1
ESYT2-004 ENSP00000275418 ENST00000275418	H7BXI1 [Direct mapping] Extended synaptotagmin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	884 aa 98 kDa	No	1
ESYT2-201 ENSP00000481296 ENST00000613624	A0A087WXU3 [Direct mapping] Extended synaptotagmin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	921 aa 102.4 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.