Expression of RCN2 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RCN2
Gene description	Reticulocalbin 2, EF-hand calcium binding domain
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in selected tissues including neurons, seminferous duct cells, placenta and epididymis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA030694 , HPA030695
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA030694	HPA030695

GENE INFORMATION
Gene name	RCN2 (HGNC Symbol)
Synonyms	E6BP, ERC-55, ERC55, TCBP49
Description	Reticulocalbin 2, EF-hand calcium binding domain (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
Chromosome	15
Cytoband	q24.3
Chromosome location (bp)	76931619 - 76954392
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117906 (version 83.38)
Entrez gene	5955
UniProt	Q14257 (UniProt - Evidence at protein level)
neXtProt	NX_Q14257
Antibodypedia	RCN2 antibodies

PROTEIN BROWSER

RCN2-001	RCN2-002	RCN2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RCN2-001 ENSP00000378349 ENST00000394885	Q14257 [Direct mapping] Reticulocalbin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] Show all	317 aa 36.9 kDa	Yes	0
RCN2-002 ENSP00000319739 ENST00000320963	Q14257 [Direct mapping] Reticulocalbin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] Show all	335 aa 39.1 kDa	Yes	0
RCN2-003 ENSP00000378347 ENST00000394883	A8MXP8 [Direct mapping] Reticulocalbin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	216 aa 24.8 kDa	Yes	0