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MUC5B

GENERAL INFORMATION

Gene name

 MUC5B

Gene description

 Mucin 5B, oligomeric mucus/gel-forming

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cervix, uterine, gallbladder)
GTEx:Tissue enriched (salivary gland)
FANTOM5:Group enriched (gallbladder, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in mucus producing cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA008246 , CAB009396
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Nasopharynx

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, gallbladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (gallbladder, tonsil)

GENE INFORMATION

Gene name

 MUC5B (HGNC Symbol)

Synonyms

 MG1, MUC5

Description

 Mucin 5B, oligomeric mucus/gel-forming (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 1223066 - 1262172

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117983 (version 83.38)

Entrez gene

 727897

UniProt

 Q9HC84 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HC84

Antibodypedia

 MUC5B antibodies

PROTEIN BROWSER
MUC5B-002
MUC5B-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MUC5B-002
ENSP00000436812
ENST00000529681
Q9HC84 [Direct mapping]
Mucin-5B
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   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0006493 [protein O-linked glycosylation]
GO:0016266 [O-glycan processing]
GO:0042742 [defense response to bacterium]
GO:0043030 [regulation of macrophage activation]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
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 5762 aa
596.3 kDa 		Yes 0
MUC5B-005
ENSP00000434539
ENST00000526859
H0YDX8 [Direct mapping]
Mucin-5B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 154 aa
16.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.