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A4GNT

GENERAL INFORMATION

Gene name

 A4GNT

Gene description

 Alpha-1,4-N-acetylglucosaminyltransferase

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (pancreatic cancer, stomach cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (stomach)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in stomach.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA008017
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008017

GENE INFORMATION

Gene name

 A4GNT (HGNC Symbol)

Synonyms

 alpha4GnT

Description

 Alpha-1,4-N-acetylglucosaminyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q22.3

Chromosome location (bp)

 138123718 - 138132387

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118017 (version 83.38)

Entrez gene

 51146

UniProt

 Q9UNA3 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UNA3

Antibodypedia

 A4GNT antibodies

PROTEIN BROWSER
A4GNT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
A4GNT-001
ENSP00000236709
ENST00000236709
Q9UNA3 [Direct mapping]
Alpha-1,4-N-acetylglucosaminyltransferase
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0000139 [Golgi membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006493 [protein O-linked glycosylation]
GO:0008375 [acetylglucosaminyltransferase activity]
GO:0009101 [glycoprotein biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0050680 [negative regulation of epithelial cell proliferation]
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 340 aa
39.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.