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MMP8

GENERAL INFORMATION

Gene name

 MMP8

Gene description

 Matrix metallopeptidase 8

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (melanoma)
HPA (cell line):Cell line enriched (WM-115)
HPA (normal tissue):Tissue enriched (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in subtypes of cells in spleen and bone marrow.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA021221 , HPA022935
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA021221
HPA022935

GENE INFORMATION

Gene name

 MMP8 (HGNC Symbol)

Synonyms

 CLG1

Description

 Matrix metallopeptidase 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Chromosome

 11

Cytoband

 q22.2

Chromosome location (bp)

 102711795 - 102727050

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118113 (version 83.38)

Entrez gene

 4317

UniProt

 P22894 (UniProt - Evidence at protein level)

neXtProt

 NX_P22894

Antibodypedia

 MMP8 antibodies

PROTEIN BROWSER
MMP8-001
MMP8-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MMP8-001
ENSP00000236826
ENST00000236826
P22894 [Direct mapping]
Neutrophil collagenase
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004222 [metalloendopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0035987 [endodermal cell differentiation]
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 467 aa
53.4 kDa 		Yes 0
MMP8-004
ENSP00000401004
ENST00000438475
H7C1M3 [Direct mapping]
Neutrophil collagenase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
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 344 aa
39.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.