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Gene name

Class

Subclass

Chromosome

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In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Antibodies

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APOA1
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

APOA1

Gene description

Apolipoprotein A-I

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enhanced (liver, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct plasma positivity in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 2 antibodies.
HPA046715 , CAB016778
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and liver cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA046715
CAB016778

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of carcinoid, breast and renal cancers showed moderate positivity. Remaining tumour tissues were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells were negative.

GENE INFORMATION

Gene name

APOA1

Synonyms

Description

Apolipoprotein A-I (HGNC Symbol)

Entrez gene summary

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q23.3

Chromosome location (bp)

116835751 - 116837950

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118137 (version 83.38)

Entrez gene

335

UniProt

P02647 (UniProt - Evidence at protein level)

neXtProt

NX_P02647

Antibodypedia

APOA1 antibodies

PROTEIN BROWSER

APOA1-001
APOA1-002
APOA1-003
APOA1-004
APOA1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APOA1-001
ENSP00000236850
ENST00000236850
P02647 [Direct mapping]
Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I
A0A024R3E3 [Target identity:100%; Query identity:100%]
Apolipoprotein A-I, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001540 [beta-amyloid binding]
GO:0001932 [regulation of protein phosphorylation]
GO:0001935 [endothelial cell proliferation]
GO:0002576 [platelet degranulation]
GO:0002740 [negative regulation of cytokine secretion involved in immune response]
GO:0005319 [lipid transporter activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007584 [response to nutrient]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008203 [cholesterol metabolic process]
GO:0008211 [glucocorticoid metabolic process]
GO:0008289 [lipid binding]
GO:0009986 [cell surface]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling]
GO:0014012 [peripheral nervous system axon regeneration]
GO:0015485 [cholesterol binding]
GO:0015914 [phospholipid transport]
GO:0017127 [cholesterol transporter activity]
GO:0018158 [protein oxidation]
GO:0018206 [peptidyl-methionine modification]
GO:0019433 [triglyceride catabolic process]
GO:0019899 [enzyme binding]
GO:0019915 [lipid storage]
GO:0030139 [endocytic vesicle]
GO:0030168 [platelet activation]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0030301 [cholesterol transport]
GO:0030325 [adrenal gland development]
GO:0031100 [organ regeneration]
GO:0031102 [neuron projection regeneration]
GO:0031210 [phosphatidylcholine binding]
GO:0031410 [cytoplasmic vesicle]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034190 [apolipoprotein receptor binding]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034365 [discoidal high-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0034774 [secretory granule lumen]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0042157 [lipoprotein metabolic process]
GO:0042158 [lipoprotein biosynthetic process]
GO:0042493 [response to drug]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043534 [blood vessel endothelial cell migration]
GO:0043627 [response to estrogen]
GO:0043691 [reverse cholesterol transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045499 [chemorepellent activity]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0050713 [negative regulation of interleukin-1 beta secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0050821 [protein stabilization]
GO:0050919 [negative chemotaxis]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0051180 [vitamin transport]
GO:0051345 [positive regulation of hydrolase activity]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0055102 [lipase inhibitor activity]
GO:0060192 [negative regulation of lipase activity]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0060354 [negative regulation of cell adhesion molecule production]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0070508 [cholesterol import]
GO:0070653 [high-density lipoprotein particle receptor binding]
GO:0071682 [endocytic vesicle lumen]
GO:0071813 [lipoprotein particle binding]
GO:0072562 [blood microparticle]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903561 [extracellular vesicle]
Show all
267 aa
30.8 kDa
Yes 0
APOA1-002
ENSP00000364469
ENST00000375320
P02647 [Direct mapping]
Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I
A0A024R3E3 [Target identity:100%; Query identity:100%]
Apolipoprotein A-I, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001540 [beta-amyloid binding]
GO:0002576 [platelet degranulation]
GO:0002740 [negative regulation of cytokine secretion involved in immune response]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0008203 [cholesterol metabolic process]
GO:0008289 [lipid binding]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling]
GO:0015485 [cholesterol binding]
GO:0017127 [cholesterol transporter activity]
GO:0018158 [protein oxidation]
GO:0018206 [peptidyl-methionine modification]
GO:0019433 [triglyceride catabolic process]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030168 [platelet activation]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0030301 [cholesterol transport]
GO:0031102 [neuron projection regeneration]
GO:0031210 [phosphatidylcholine binding]
GO:0031410 [cytoplasmic vesicle]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034190 [apolipoprotein receptor binding]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0034774 [secretory granule lumen]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0042157 [lipoprotein metabolic process]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043691 [reverse cholesterol transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045499 [chemorepellent activity]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0050713 [negative regulation of interleukin-1 beta secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0050821 [protein stabilization]
GO:0050919 [negative chemotaxis]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0051180 [vitamin transport]
GO:0051345 [positive regulation of hydrolase activity]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0060354 [negative regulation of cell adhesion molecule production]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0070508 [cholesterol import]
GO:0070653 [high-density lipoprotein particle receptor binding]
GO:0071682 [endocytic vesicle lumen]
GO:0072562 [blood microparticle]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903561 [extracellular vesicle]
Show all
267 aa
30.8 kDa
Yes 0
APOA1-003
ENSP00000364472
ENST00000375323
P02647 [Direct mapping]
Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I
A0A024R3E3 [Target identity:100%; Query identity:100%]
Apolipoprotein A-I, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001540 [beta-amyloid binding]
GO:0002576 [platelet degranulation]
GO:0002740 [negative regulation of cytokine secretion involved in immune response]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0008203 [cholesterol metabolic process]
GO:0008289 [lipid binding]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling]
GO:0015485 [cholesterol binding]
GO:0017127 [cholesterol transporter activity]
GO:0018158 [protein oxidation]
GO:0018206 [peptidyl-methionine modification]
GO:0019433 [triglyceride catabolic process]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030168 [platelet activation]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0030301 [cholesterol transport]
GO:0031102 [neuron projection regeneration]
GO:0031210 [phosphatidylcholine binding]
GO:0031410 [cytoplasmic vesicle]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034190 [apolipoprotein receptor binding]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0034774 [secretory granule lumen]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0042157 [lipoprotein metabolic process]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043691 [reverse cholesterol transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045499 [chemorepellent activity]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0050713 [negative regulation of interleukin-1 beta secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0050821 [protein stabilization]
GO:0050919 [negative chemotaxis]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0051180 [vitamin transport]
GO:0051345 [positive regulation of hydrolase activity]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0060354 [negative regulation of cell adhesion molecule production]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0070508 [cholesterol import]
GO:0070653 [high-density lipoprotein particle receptor binding]
GO:0071682 [endocytic vesicle lumen]
GO:0072562 [blood microparticle]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903561 [extracellular vesicle]
Show all
267 aa
30.8 kDa
Yes 0
APOA1-004
ENSP00000352471
ENST00000359492
P02647 [Direct mapping]
Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I
A0A024R3E3 [Target identity:100%; Query identity:100%]
Apolipoprotein A-I, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001540 [beta-amyloid binding]
GO:0002576 [platelet degranulation]
GO:0002740 [negative regulation of cytokine secretion involved in immune response]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0008203 [cholesterol metabolic process]
GO:0008289 [lipid binding]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling]
GO:0015485 [cholesterol binding]
GO:0017127 [cholesterol transporter activity]
GO:0018158 [protein oxidation]
GO:0018206 [peptidyl-methionine modification]
GO:0019433 [triglyceride catabolic process]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030168 [platelet activation]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0030301 [cholesterol transport]
GO:0031102 [neuron projection regeneration]
GO:0031210 [phosphatidylcholine binding]
GO:0031410 [cytoplasmic vesicle]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034190 [apolipoprotein receptor binding]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0034774 [secretory granule lumen]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0042157 [lipoprotein metabolic process]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043691 [reverse cholesterol transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045499 [chemorepellent activity]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0050713 [negative regulation of interleukin-1 beta secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0050821 [protein stabilization]
GO:0050919 [negative chemotaxis]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0051180 [vitamin transport]
GO:0051345 [positive regulation of hydrolase activity]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0060354 [negative regulation of cell adhesion molecule production]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0070508 [cholesterol import]
GO:0070653 [high-density lipoprotein particle receptor binding]
GO:0071682 [endocytic vesicle lumen]
GO:0072562 [blood microparticle]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903561 [extracellular vesicle]
Show all
267 aa
30.8 kDa
Yes 0
APOA1-005
ENSP00000364478
ENST00000375329
F8W696 [Direct mapping]
Apolipoprotein A-I
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0019433 [triglyceride catabolic process]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0031102 [neuron projection regeneration]
GO:0031210 [phosphatidylcholine binding]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0042157 [lipoprotein metabolic process]
GO:0042627 [chylomicron]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0051006 [positive regulation of lipoprotein lipase activity]
Show all
245 aa
27.9 kDa
No 0

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