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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CAMSAP2
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CAMSAP2

Gene description

Calmodulin regulated spectrin-associated protein family, member 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression, highest expression in the brain.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA026304 , HPA026511 , HPA027302
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY

HPA026304
HPA026511
HPA027302

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most of the malignant cells displayed moderate cytoplasmic and membranous positivity. Several cases of malignant gliomas, pancreatic and liver cancers showed strong staining. Several cases of renal and prostate cancers were weakly stained.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant tissues showed moderate cytoplasmic staining. Several malignant gliomas, malignant melanomas, testicular and urothelial cancers exhibited strong staining.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant cells displayed moderate to strong cytoplasmic immunoreactivity, in some cases accentuated to the plasma membrane.

GENE INFORMATION

Gene name

CAMSAP2 (HGNC Symbol)

Synonyms

CAMSAP1L1, KIAA1078

Description

Calmodulin regulated spectrin-associated protein family, member 2 (HGNC Symbol)

Entrez gene summary

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

200739558 - 200860704

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118200 (version 83.38)

Entrez gene

23271

UniProt

Q08AD1 (UniProt - Evidence at protein level)

neXtProt

NX_Q08AD1

Antibodypedia

CAMSAP2 antibodies

PROTEIN BROWSER

CAMSAP2-001
CAMSAP2-002
CAMSAP2-003
CAMSAP2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAMSAP2-001
ENSP00000236925
ENST00000236925
Q08AD1 [Direct mapping]
Calmodulin-regulated spectrin-associated protein 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0008017 [microtubule binding]
GO:0033043 [regulation of organelle organization]
GO:0036449 [microtubule minus-end]
GO:0051011 [microtubule minus-end binding]
Show all
1489 aa
168.1 kDa
No 0
CAMSAP2-002
ENSP00000351684
ENST00000358823
Q08AD1 [Direct mapping]
Calmodulin-regulated spectrin-associated protein 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0008017 [microtubule binding]
GO:0033043 [regulation of organelle organization]
GO:0051011 [microtubule minus-end binding]
Show all
1478 aa
166.7 kDa
No 0
CAMSAP2-003
ENSP00000434766
ENST00000475326
H0YE13 [Direct mapping]
Calmodulin-regulated spectrin-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008017 [microtubule binding]
Show all
56 aa
5.9 kDa
No 0
CAMSAP2-004
ENSP00000416800
ENST00000413307
Q08AD1 [Direct mapping]
Calmodulin-regulated spectrin-associated protein 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0008017 [microtubule binding]
GO:0033043 [regulation of organelle organization]
GO:0051011 [microtubule minus-end binding]
Show all
1462 aa
165.1 kDa
No 0

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