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TNP1

GENERAL INFORMATION

Gene name

 TNP1

Gene description

 Transition protein 1 (during histone to protamine replacement)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (liver cancer, testis cancer)
HPA (cell line):Cell line enhanced (Hep G2, U-2197)
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in spermatids, testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA044387
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (liver cancer, testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044387

GENE INFORMATION

Gene name

 TNP1

Synonyms

Description

 Transition protein 1 (during histone to protamine replacement) (HGNC Symbol)

Entrez gene summary

 Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 216859458 - 216860064

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118245 (version 83.38)

Entrez gene

 7141

UniProt

 P09430 (UniProt - Evidence at protein level)

neXtProt

 NX_P09430

Antibodypedia

 TNP1 antibodies

PROTEIN BROWSER
TNP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNP1-001
ENSP00000236979
ENST00000236979
P09430 [Direct mapping]
Spermatid nuclear transition protein 1
Q4ZG82 [Target identity:100%; Query identity:100%]
Putative uncharacterized protein TNP1; Transition protein 1; Transition protein 1 (During histone to protamine replacement)
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Predicted intracellular proteins
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GO:0000012 [single strand break repair]
GO:0000786 [nucleosome]
GO:0001673 [male germ cell nucleus]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006342 [chromatin silencing]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0007286 [spermatid development]
GO:0007289 [spermatid nucleus differentiation]
GO:0007290 [spermatid nucleus elongation]
GO:0019953 [sexual reproduction]
GO:0030317 [sperm motility]
GO:0035042 [fertilization, exchange of chromosomal proteins]
GO:0045892 [negative regulation of transcription, DNA-templated]
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 55 aa
6.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.