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NRP2

GENERAL INFORMATION

Gene name

 NRP2

Gene description

 Neuropilin 2

Protein class

 Cancer-related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CAPAN-2, U-251 MG)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, most abundant in smooth muscle cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039980
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039980

GENE INFORMATION

Gene name

 NRP2 (HGNC Symbol)

Synonyms

 VEGF165R2

Description

 Neuropilin 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q33.3

Chromosome location (bp)

 205681990 - 205798133

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118257 (version 83.38)

Entrez gene

 8828

UniProt

 O60462 (UniProt - Evidence at protein level)

neXtProt

 NX_O60462

Antibodypedia

 NRP2 antibodies

PROTEIN BROWSER
NRP2-001
NRP2-002
NRP2-003
NRP2-004
NRP2-005
NRP2-006
NRP2-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NRP2-001
ENSP00000353582
ENST00000360409
X5D2Q8 [Direct mapping]
Neuropilin 2 isoform A; Neuropilin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001755 [neural crest cell migration]
GO:0001764 [neuron migration]
GO:0005021 [vascular endothelial growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0007411 [axon guidance]
GO:0007507 [heart development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017154 [semaphorin receptor activity]
GO:0021612 [facial nerve structural organization]
GO:0021649 [vestibulocochlear nerve structural organization]
GO:0021675 [nerve development]
GO:0021828 [gonadotrophin-releasing hormone neuronal migration to the hypothalamus]
GO:0030424 [axon]
GO:0036486 [ventral trunk neural crest cell migration]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0046872 [metal ion binding]
GO:0048846 [axon extension involved in axon guidance]
GO:0050919 [negative chemotaxis]
GO:0061549 [sympathetic ganglion development]
GO:0061551 [trigeminal ganglion development]
GO:0061552 [ganglion morphogenesis]
GO:0097374 [sensory neuron axon guidance]
GO:0097490 [sympathetic neuron projection extension]
GO:0097491 [sympathetic neuron projection guidance]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1902285 [semaphorin-plexin signaling pathway involved in neuron projection guidance]
GO:1903375 [facioacoustic ganglion development]
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 931 aa
104.8 kDa 		Yes 1
NRP2-002
ENSP00000272849
ENST00000272849
O60462 [Direct mapping]
Neuropilin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002116 [semaphorin receptor complex]
GO:0004872 [receptor activity]
GO:0005021 [vascular endothelial growth factor-activated receptor activity]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017154 [semaphorin receptor activity]
GO:0019838 [growth factor binding]
GO:0019955 [cytokine binding]
GO:0021675 [nerve development]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048846 [axon extension involved in axon guidance]
GO:0061549 [sympathetic ganglion development]
GO:0097490 [sympathetic neuron projection extension]
GO:0097491 [sympathetic neuron projection guidance]
GO:1902285 [semaphorin-plexin signaling pathway involved in neuron projection guidance]
Show all
 906 aa
102 kDa 		Yes 1
NRP2-003
ENSP00000349632
ENST00000357118
A0A024R412 [Direct mapping]
Neuropilin 2, isoform CRA_c; Neuropilin-2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005021 [vascular endothelial growth factor-activated receptor activity]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017154 [semaphorin receptor activity]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0046872 [metal ion binding]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 901 aa
101.4 kDa 		Yes 1
NRP2-004
ENSP00000407626
ENST00000412873
A0A024R3W6 [Direct mapping]
Neuropilin 2, isoform CRA_h; Neuropilin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005021 [vascular endothelial growth factor-activated receptor activity]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017154 [semaphorin receptor activity]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0046872 [metal ion binding]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 909 aa
102.2 kDa 		Yes 1
NRP2-005
ENSP00000350432
ENST00000357785
Q7LBX6 [Direct mapping]
Neuropilin 2; Neuropilin 2, isoform CRA_b; Neuropilin-2; Neuropilin-2a(17)
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005021 [vascular endothelial growth factor-activated receptor activity]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017154 [semaphorin receptor activity]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0046872 [metal ion binding]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 926 aa
104.3 kDa 		Yes 1
NRP2-006
ENSP00000387519
ENST00000417189
O60462 [Direct mapping]
Neuropilin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002116 [semaphorin receptor complex]
GO:0004872 [receptor activity]
GO:0005021 [vascular endothelial growth factor-activated receptor activity]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017154 [semaphorin receptor activity]
GO:0019838 [growth factor binding]
GO:0019955 [cytokine binding]
GO:0021675 [nerve development]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048846 [axon extension involved in axon guidance]
GO:0061549 [sympathetic ganglion development]
GO:0097490 [sympathetic neuron projection extension]
GO:0097491 [sympathetic neuron projection guidance]
GO:1902285 [semaphorin-plexin signaling pathway involved in neuron projection guidance]
Show all
 555 aa
62.4 kDa 		Yes 0
NRP2-009
ENSP00000404279
ENST00000450507
C9JH98 [Direct mapping]
Neuropilin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005021 [vascular endothelial growth factor-activated receptor activity]
GO:0007411 [axon guidance]
GO:0017154 [semaphorin receptor activity]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 102 aa
11.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.