Cell atlas - LRMP - The Human Protein Atlas

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LRMP

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus
	Vesicles

Human cell
	Cytosol
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	LRMP
Gene description	Lymphoid-restricted membrane protein
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the nucleus & cytosol.
RNA cell category	Group enriched (U-698, Daudi, REH)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)
Additional location	In addition localized to the Nucleus (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA002967
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-698, Daudi, REH) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the nucleus & cytosol.

Main location

Vesicles (supported)

Additional location

Nucleus (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002967	RT4	Nucleoplasm	Intensity
			Vesicles
			Cytosol
	HPA002967	U-2 OS	Nucleus
	HPA002967	U-2 OS	Vesicles
	HPA002967	U-251 MG	Nucleus
	HPA002967	U-251 MG	Vesicles

GENE INFORMATION
Gene name	LRMP (HGNC Symbol)
Synonyms	JAW1
Description	Lymphoid-restricted membrane protein (HGNC Symbol)
Entrez gene summary	The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	25021002 - 25108334
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118308 (version 83.38)
Entrez gene	4033
UniProt	Q12912 (UniProt - Evidence at protein level)
neXtProt	NX_Q12912
Antibodypedia	LRMP antibodies

PROTEIN BROWSER

LRMP-002	LRMP-003	LRMP-005	LRMP-006	LRMP-007	LRMP-008	LRMP-011	LRMP-012	LRMP-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRMP-002 ENSP00000446496 ENST00000548766	Q12912 [Direct mapping] Lymphoid-restricted membrane protein Processed lymphoid-restricted membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0002376 [immune system process] GO:0005635 [nuclear envelope] GO:0005694 [chromosome] GO:0005789 [endoplasmic reticulum membrane] GO:0005815 [microtubule organizing center] GO:0005887 [integral component of plasma membrane] GO:0006903 [vesicle targeting] GO:0006906 [vesicle fusion] GO:0007338 [single fertilization] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	499 aa 56.2 kDa	No	1
LRMP-003 ENSP00000346442 ENST00000354454	Q12912 [Direct mapping] Lymphoid-restricted membrane protein Processed lymphoid-restricted membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0002376 [immune system process] GO:0005635 [nuclear envelope] GO:0005694 [chromosome] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005815 [microtubule organizing center] GO:0005887 [integral component of plasma membrane] GO:0006903 [vesicle targeting] GO:0006906 [vesicle fusion] GO:0007338 [single fertilization] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	499 aa 56.2 kDa	No	1
LRMP-005 ENSP00000450246 ENST00000547044	Q12912 [Direct mapping] Lymphoid-restricted membrane protein Processed lymphoid-restricted membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0002376 [immune system process] GO:0005635 [nuclear envelope] GO:0005694 [chromosome] GO:0005789 [endoplasmic reticulum membrane] GO:0005815 [microtubule organizing center] GO:0005887 [integral component of plasma membrane] GO:0006903 [vesicle targeting] GO:0006906 [vesicle fusion] GO:0007338 [single fertilization] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	499 aa 56.2 kDa	No	1
LRMP-006 ENSP00000448534 ENST00000550945	F8VRE4 [Direct mapping] Lymphoid-restricted membrane protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		118 aa 13 kDa	No	0
LRMP-007 ENSP00000452116 ENST00000557489	G3V513 [Direct mapping] Lymphoid-restricted membrane protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		120 aa 13.3 kDa	No	0
LRMP-008 ENSP00000444056 ENST00000536173	F5H006 [Direct mapping] Lymphoid-restricted membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	446 aa 50.4 kDa	No	1
LRMP-011 ENSP00000451048 ENST00000556887	A0A0G2JL87 [Direct mapping] Lymphoid-restricted membrane protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		8 aa 0.9 kDa	No	0
LRMP-012 ENSP00000450634 ENST00000554942	G3V2F6 [Direct mapping] Lymphoid-restricted membrane protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		77 aa 8.4 kDa	No	0
LRMP-019 ENSP00000450767 ENST00000555885	H0YJ39 [Direct mapping] Lymphoid-restricted membrane protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 8.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.