Tissue expression of USP35 - Summary - The Human Protein Atlas

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USP35

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	USP35
Gene description	Ubiquitin specific peptidase 35
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (parathyroid gland)
GTEx:	Expressed in all
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Nuclear and cytoplasmic expression in several cell types, including Leydig cells and skeletal myocytes.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA055213 , HPA058592
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	USP35 (HGNC Symbol)
Synonyms	KIAA1372
Description	Ubiquitin specific peptidase 35 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q14.1
Chromosome location (bp)	78188812 - 78214711
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118369 (version 83.38)
Entrez gene	57558
UniProt	Q9P2H5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P2H5
Antibodypedia	USP35 antibodies

PROTEIN BROWSER

USP35-001	USP35-004	USP35-006	USP35-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
USP35-001 ENSP00000431876 ENST00000529308	Q9P2H5 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 35 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005488 [binding] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	1018 aa 113.4 kDa	No	0
USP35-004 ENSP00000435468 ENST00000530267	E9PK78 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	586 aa 65.7 kDa	No	0
USP35-006 ENSP00000436001 ENST00000528910	E9PRM2 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 35 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	298 aa 33.8 kDa	No	0
USP35-007 ENSP00000434942 ENST00000526425	Q9P2H5 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 35 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	749 aa 84.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.