Expression of CNR1 in cancer - Summary - The Human Protein Atlas

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CNR1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CNR1
Gene description	Cannabinoid receptor 1 (brain)
Protein class	FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enhanced (AF22, ASC TERT1, RPTEC TERT1, TIME, U-698)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression, most abundant in CNS and immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. CAB005603
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB005603

GENE INFORMATION
Gene name	CNR1 (HGNC Symbol)
Synonyms	CANN6, CB-R, CB1, CB1A, CB1K5, CNR
Description	Cannabinoid receptor 1 (brain) (HGNC Symbol)
Entrez gene summary	This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
Chromosome	6
Cytoband	q15
Chromosome location (bp)	88139864 - 88166359
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118432 (version 83.38)
Entrez gene	1268
UniProt	P21554 (UniProt - Evidence at protein level)
neXtProt	NX_P21554
Antibodypedia	CNR1 antibodies

PROTEIN BROWSER

CNR1-001	CNR1-002	CNR1-003	CNR1-004	CNR1-005	CNR1-006	CNR1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNR1-001 ENSP00000358513 ENST00000369501	P21554 [Direct mapping] Cannabinoid receptor 1 S5TLS4 [Target identity:100%; Query identity:100%] Cannabinoid receptor 1 (Brain) Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus] GO:0004930 [G-protein coupled receptor activity] GO:0004949 [cannabinoid receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007283 [spermatogenesis] GO:0007413 [axonal fasciculation] GO:0007568 [aging] GO:0007584 [response to nutrient] GO:0007611 [learning or memory] GO:0007613 [memory] GO:0008144 [drug binding] GO:0010976 [positive regulation of neuron projection development] GO:0016021 [integral component of membrane] GO:0019216 [regulation of lipid metabolic process] GO:0019233 [sensory perception of pain] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031622 [positive regulation of fever generation] GO:0031999 [negative regulation of fatty acid beta-oxidation] GO:0032228 [regulation of synaptic transmission, GABAergic] GO:0032496 [response to lipopolysaccharide] GO:0033004 [negative regulation of mast cell activation] GO:0033602 [negative regulation of dopamine secretion] GO:0035094 [response to nicotine] GO:0038171 [cannabinoid signaling pathway] GO:0042220 [response to cocaine] GO:0042593 [glucose homeostasis] GO:0043065 [positive regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043271 [negative regulation of ion transport] GO:0043278 [response to morphine] GO:0045121 [membrane raft] GO:0045471 [response to ethanol] GO:0045759 [negative regulation of action potential] GO:0045776 [negative regulation of blood pressure] GO:0045777 [positive regulation of blood pressure] GO:0050796 [regulation of insulin secretion] GO:0051001 [negative regulation of nitric-oxide synthase activity] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0060135 [maternal process involved in female pregnancy] GO:0060259 [regulation of feeding behavior] GO:0060405 [regulation of penile erection] Show all	472 aa 52.9 kDa	No	7
CNR1-002 ENSP00000446819 ENST00000549890	P21554 [Direct mapping] Cannabinoid receptor 1 S5TLS4 [Target identity:100%; Query identity:100%] Cannabinoid receptor 1 (Brain) Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004949 [cannabinoid receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038171 [cannabinoid signaling pathway] Show all	472 aa 52.9 kDa	No	7
CNR1-003 ENSP00000355418 ENST00000362094	F8W908 [Direct mapping] Cannabinoid receptor 1 Show all	Predicted intracellular proteins Show all		36 aa 4 kDa	No	0
CNR1-004 ENSP00000420188 ENST00000468898	P21554 [Direct mapping] Cannabinoid receptor 1 V5KA96 [Target identity:100%; Query identity:100%] Cannabinoid receptor 1 transcript variant 2 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004949 [cannabinoid receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038171 [cannabinoid signaling pathway] Show all	439 aa 49.1 kDa	No	7
CNR1-005 ENSP00000412192 ENST00000428600	P21554 [Direct mapping] Cannabinoid receptor 1 S5TLS4 [Target identity:100%; Query identity:100%] Cannabinoid receptor 1 (Brain) Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004949 [cannabinoid receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038171 [cannabinoid signaling pathway] Show all	472 aa 52.9 kDa	No	7
CNR1-006 ENSP00000358511 ENST00000369499	P21554 [Direct mapping] Cannabinoid receptor 1 S5TLS4 [Target identity:100%; Query identity:100%] Cannabinoid receptor 1 (Brain) Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004949 [cannabinoid receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038171 [cannabinoid signaling pathway] Show all	472 aa 52.9 kDa	No	7
CNR1-007 ENSP00000446702 ENST00000551417	F8W187 [Direct mapping] Cannabinoid receptor 1 Show all	Predicted intracellular proteins Show all	GO:0004949 [cannabinoid receptor activity] GO:0016021 [integral component of membrane] GO:0038171 [cannabinoid signaling pathway] Show all	78 aa 8.7 kDa	No	0

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