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TNFAIP3

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GENERAL INFORMATION

Gene name

 TNFAIP3

Gene description

 Tumor necrosis factor, alpha-induced protein 3

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the centrosome. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (REH, Karpas-707)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Centrosome (approved)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA002116
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (REH, Karpas-707)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the centrosome. In addition localized to the cytosol.

Main location

 Centrosome (approved)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA002116 A-431 Centrosome
Cytosol
HPA002116 U-2 OS Centrosome
Cytosol
HPA002116 U-251 MG Centrosome
Cytosol

GENE INFORMATION

Gene name

 TNFAIP3 (HGNC Symbol)

Synonyms

 A20, OTUD7C

Description

 Tumor necrosis factor, alpha-induced protein 3 (HGNC Symbol)

Entrez gene summary

 This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 6

Cytoband

 q23.3

Chromosome location (bp)

 137867188 - 137883312

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118503 (version 83.38)

Entrez gene

 7128

UniProt

 P21580 (UniProt - Evidence at protein level)

neXtProt

 NX_P21580

Antibodypedia

 TNFAIP3 antibodies

PROTEIN BROWSER
TNFAIP3-001
TNFAIP3-002
TNFAIP3-003
TNFAIP3-004
TNFAIP3-201
TNFAIP3-202
TNFAIP3-203
TNFAIP3-204
TNFAIP3-205
TNFAIP3-206

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNFAIP3-001
ENSP00000237289
ENST00000237289
P21580 [Direct mapping]
Tumor necrosis factor alpha-induced protein 3 A20p50 A20p37
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001922 [B-1 B cell homeostasis]
GO:0002020 [protease binding]
GO:0002237 [response to molecule of bacterial origin]
GO:0002634 [regulation of germinal center formation]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016579 [protein deubiquitination]
GO:0016874 [ligase activity]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032480 [negative regulation of type I interferon production]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway]
GO:0034140 [negative regulation of toll-like receptor 3 signaling pathway]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0035871 [protein K11-linked deubiquitination]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045779 [negative regulation of bone resorption]
GO:0045824 [negative regulation of innate immune response]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050691 [regulation of defense response to virus by host]
GO:0050727 [regulation of inflammatory response]
GO:0050728 [negative regulation of inflammatory response]
GO:0050869 [negative regulation of B cell activation]
GO:0051259 [protein oligomerization]
GO:0061043 [regulation of vascular wound healing]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070530 [K63-linked polyubiquitin binding]
GO:0070536 [protein K63-linked deubiquitination]
GO:0070936 [protein K48-linked ubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071947 [protein deubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0072573 [tolerance induction to lipopolysaccharide]
GO:0090291 [negative regulation of osteoclast proliferation]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2000349 [negative regulation of CD40 signaling pathway]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
 790 aa
89.6 kDa 		No 0
TNFAIP3-002
ENSP00000393577
ENST00000421450
Q5VXR0 [Direct mapping]
Tumor necrosis factor alpha-induced protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 26 aa
3 kDa 		No 0
TNFAIP3-003
ENSP00000401562
ENST00000420009
Q5VXQ8 [Direct mapping]
Tumor necrosis factor alpha-induced protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 162 aa
19.2 kDa 		No 0
TNFAIP3-004
ENSP00000409845
ENST00000433680
Q5VXQ9 [Direct mapping]
Tumor necrosis factor alpha-induced protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 98 aa
11.8 kDa 		No 0
TNFAIP3-201
ENSP00000481570
ENST00000612899
P21580 [Direct mapping]
Tumor necrosis factor alpha-induced protein 3 A20p50 A20p37
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001922 [B-1 B cell homeostasis]
GO:0002020 [protease binding]
GO:0002237 [response to molecule of bacterial origin]
GO:0002634 [regulation of germinal center formation]
GO:0002677 [negative regulation of chronic inflammatory response]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016579 [protein deubiquitination]
GO:0016874 [ligase activity]
GO:0019900 [kinase binding]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032480 [negative regulation of type I interferon production]
GO:0032495 [response to muramyl dipeptide]
GO:0032691 [negative regulation of interleukin-1 beta production]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway]
GO:0034140 [negative regulation of toll-like receptor 3 signaling pathway]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0034148 [negative regulation of toll-like receptor 5 signaling pathway]
GO:0035871 [protein K11-linked deubiquitination]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045779 [negative regulation of bone resorption]
GO:0045824 [negative regulation of innate immune response]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050691 [regulation of defense response to virus by host]
GO:0050727 [regulation of inflammatory response]
GO:0050728 [negative regulation of inflammatory response]
GO:0050869 [negative regulation of B cell activation]
GO:0051259 [protein oligomerization]
GO:0060548 [negative regulation of cell death]
GO:0061043 [regulation of vascular wound healing]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070429 [negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway]
GO:0070433 [negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0070530 [K63-linked polyubiquitin binding]
GO:0070536 [protein K63-linked deubiquitination]
GO:0070936 [protein K48-linked ubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071947 [protein deubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0072573 [tolerance induction to lipopolysaccharide]
GO:0072666 [establishment of protein localization to vacuole]
GO:0090291 [negative regulation of osteoclast proliferation]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000349 [negative regulation of CD40 signaling pathway]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
 790 aa
89.6 kDa 		No 0
TNFAIP3-202
ENSP00000481122
ENST00000614035
A0A087WXL5 [Direct mapping]
Tumor necrosis factor alpha-induced protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0008270 [zinc ion binding]
Show all
 470 aa
54.3 kDa 		No 0
TNFAIP3-203
ENSP00000479556
ENST00000615468
A0A087WVN3 [Direct mapping]
Tumor necrosis factor alpha-induced protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 214 aa
25.5 kDa 		No 0
TNFAIP3-204
ENSP00000478438
ENST00000619035
A0A087WU80 [Direct mapping]
Tumor necrosis factor alpha-induced protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0008270 [zinc ion binding]
Show all
 749 aa
84.9 kDa 		No 0
TNFAIP3-205
ENSP00000481454
ENST00000620204
D3TTY5 [Direct mapping]
Truncated tumor necrosis factor alpha-induced protein 3; Tumor necrosis factor alpha-induced protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0008270 [zinc ion binding]
Show all
 669 aa
76.2 kDa 		No 0
TNFAIP3-206
ENSP00000484332
ENST00000621150
A0A087X1N1 [Direct mapping]
Tumor necrosis factor alpha-induced protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0008270 [zinc ion binding]
Show all
 531 aa
61.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.