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SGK1

GENERAL INFORMATION

Gene name

 SGK1

Gene description

 Serum/glucocorticoid regulated kinase 1

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
CAB022085 , CAB025148
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SGK1 (HGNC Symbol)

Synonyms

 SGK

Description

 Serum/glucocorticoid regulated kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

Chromosome

 6

Cytoband

 q23.2

Chromosome location (bp)

 134169246 - 134318112

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118515 (version 83.38)

Entrez gene

 6446

UniProt

 O00141 (UniProt - Evidence at protein level)

neXtProt

 NX_O00141

Antibodypedia

 SGK1 antibodies

PROTEIN BROWSER
SGK1-001
SGK1-002
SGK1-004
SGK1-009
SGK1-010
SGK1-011
SGK1-017
SGK1-018
SGK1-020
SGK1-021

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SGK1-001
ENSP00000356832
ENST00000367858
O00141 [Direct mapping]
Serine/threonine-protein kinase Sgk1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007019 [microtubule depolymerization]
GO:0007616 [long-term memory]
GO:0008217 [regulation of blood pressure]
GO:0008542 [visual learning]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035091 [phosphatidylinositol binding]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043402 [glucocorticoid mediated signaling pathway]
GO:0043423 [3-phosphoinositide-dependent protein kinase binding]
GO:0048037 [cofactor binding]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048812 [neuron projection morphogenesis]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0050790 [regulation of catalytic activity]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051726 [regulation of cell cycle]
GO:0055085 [transmembrane transport]
GO:0060453 [regulation of gastric acid secretion]
GO:0070294 [renal sodium ion absorption]
Show all
 526 aa
59.9 kDa 		No 0
SGK1-002
ENSP00000435724
ENST00000524929
Q7Z3I4 [Direct mapping]
Putative uncharacterized protein DKFZp686H1615; Serine/threonine-protein kinase Sgk1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 153 aa
17.5 kDa 		No 0
SGK1-004
ENSP00000431705
ENST00000460769
H0YCJ3 [Direct mapping]
Serine/threonine-protein kinase Sgk1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 55 aa
5.8 kDa 		No 0
SGK1-009
ENSP00000237305
ENST00000237305
O00141 [Direct mapping]
Serine/threonine-protein kinase Sgk1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007616 [long-term memory]
GO:0008217 [regulation of blood pressure]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0048812 [neuron projection morphogenesis]
GO:0050790 [regulation of catalytic activity]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055085 [transmembrane transport]
GO:0060453 [regulation of gastric acid secretion]
GO:0070294 [renal sodium ion absorption]
Show all
 431 aa
48.9 kDa 		No 0
SGK1-010
ENSP00000396242
ENST00000413996
O00141 [Direct mapping]
Serine/threonine-protein kinase Sgk1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007616 [long-term memory]
GO:0008217 [regulation of blood pressure]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0048812 [neuron projection morphogenesis]
GO:0050790 [regulation of catalytic activity]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055085 [transmembrane transport]
GO:0060453 [regulation of gastric acid secretion]
GO:0070294 [renal sodium ion absorption]
Show all
 445 aa
50.6 kDa 		No 0
SGK1-011
ENSP00000356831
ENST00000367857
O00141 [Direct mapping]
Serine/threonine-protein kinase Sgk1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007616 [long-term memory]
GO:0008217 [regulation of blood pressure]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035091 [phosphatidylinositol binding]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0048812 [neuron projection morphogenesis]
GO:0050790 [regulation of catalytic activity]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055085 [transmembrane transport]
GO:0060453 [regulation of gastric acid secretion]
GO:0070294 [renal sodium ion absorption]
Show all
 421 aa
47.9 kDa 		No 0
SGK1-017
ENSP00000434450
ENST00000528577
O00141 [Direct mapping]
Serine/threonine-protein kinase Sgk1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007616 [long-term memory]
GO:0008217 [regulation of blood pressure]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0048812 [neuron projection morphogenesis]
GO:0050790 [regulation of catalytic activity]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055085 [transmembrane transport]
GO:0060453 [regulation of gastric acid secretion]
GO:0070294 [renal sodium ion absorption]
Show all
 459 aa
52.1 kDa 		No 0
SGK1-018
ENSP00000434302
ENST00000475719
E9PR89 [Direct mapping]
Serine/threonine-protein kinase Sgk1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
Show all
 387 aa
43.8 kDa 		No 0
SGK1-020
ENSP00000436470
ENST00000533224
E9PP33 [Direct mapping]
Serine/threonine-protein kinase Sgk1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 60 aa
6.9 kDa 		No 0
SGK1-021
ENSP00000435577
ENST00000461976
E9PJN2 [Direct mapping]
Serine/threonine-protein kinase Sgk1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0035091 [phosphatidylinositol binding]
Show all
 144 aa
16.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.