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DCLRE1B

GENERAL INFORMATION

Gene name

 DCLRE1B

Gene description

 DNA cross-link repair 1B

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DCLRE1B (HGNC Symbol)

Synonyms

 FLJ12810, FLJ13998, SNM1B

Description

 DNA cross-link repair 1B (HGNC Symbol)

Entrez gene summary

 DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008]

Chromosome

 1

Cytoband

 p13.2

Chromosome location (bp)

 113905141 - 113914086

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118655 (version 83.38)

Entrez gene

 64858

UniProt

 Q9H816 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H816

Antibodypedia

 DCLRE1B antibodies

PROTEIN BROWSER
DCLRE1B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCLRE1B-001
ENSP00000358576
ENST00000369563
Q9H816 [Direct mapping]
5' exonuclease Apollo
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0000075 [cell cycle checkpoint]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0008409 [5'-3' exonuclease activity]
GO:0031627 [telomeric loop formation]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0031860 [telomeric 3' overhang formation]
GO:0035312 [5'-3' exodeoxyribonuclease activity]
GO:0036297 [interstrand cross-link repair]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 532 aa
60 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.