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MYL12B

GENERAL INFORMATION

Gene name

 MYL12B

Gene description

 Myosin, light chain 12B, regulatory

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in myocytes.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 3 antibodies.
HPA039262 , HPA045244 , HPA059197
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MYL12B (HGNC Symbol)

Synonyms

 MRLC2

Description

 Myosin, light chain 12B, regulatory (HGNC Symbol)

Entrez gene summary

 The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]

Chromosome

 18

Cytoband

 p11.31

Chromosome location (bp)

 3261909 - 3278284

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118680 (version 83.38)

Entrez gene

 103910

UniProt

 O14950 (UniProt - Evidence at protein level)

neXtProt

 NX_O14950

Antibodypedia

 MYL12B antibodies

PROTEIN BROWSER
MYL12B-001
MYL12B-002
MYL12B-003
MYL12B-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYL12B-001
ENSP00000237500
ENST00000237500
O14950 [Direct mapping]
Myosin regulatory light chain 12B
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 172 aa
19.8 kDa 		No 0
MYL12B-002
ENSP00000463559
ENST00000581193
O14950 [Direct mapping]
Myosin regulatory light chain 12B
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005903 [brush border]
GO:0006936 [muscle contraction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008360 [regulation of cell shape]
GO:0016460 [myosin II complex]
GO:0030018 [Z disc]
GO:0032036 [myosin heavy chain binding]
GO:0043234 [protein complex]
GO:0045177 [apical part of cell]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 172 aa
19.8 kDa 		No 0
MYL12B-003
ENSP00000383037
ENST00000400175
O14950 [Direct mapping]
Myosin regulatory light chain 12B
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 172 aa
19.8 kDa 		No 0
MYL12B-004
ENSP00000464464
ENST00000584539
O14950 [Direct mapping]
Myosin regulatory light chain 12B
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 172 aa
19.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.