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Cancer cells generally displayed weak to moderate cytoplasmic staining. Staining in luminal membranes was observed in a number of cancers for example, colorectal, endometrial and liver. A few melanomas and urothelial cancers showed strong staining. Skin and testicular cancers were negative.
Urothelial, testis, endometrial, cervical cancers and melanomas and gliomas showed moderate to strong cytoplasmic positivity. Remaining cancers were weakly stained or negative.
This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]