Expression of CCNI in cancer - Summary - The Human Protein Atlas

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CCNI

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCNI
Gene description	Cyclin I
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in many tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA039853 , CAB010206
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039853	CAB010206

GENE INFORMATION
Gene name	CCNI (HGNC Symbol)
Synonyms	CCNI1
Description	Cyclin I (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. The function of this cyclin has not yet been determined. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q21.1
Chromosome location (bp)	77047158 - 77076005
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118816 (version 83.38)
Entrez gene	10983
UniProt	Q14094 (UniProt - Evidence at transcript level)
neXtProt	NX_Q14094
Antibodypedia	CCNI antibodies

PROTEIN BROWSER

CCNI-001	CCNI-002	CCNI-003	CCNI-004	CCNI-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCNI-001 ENSP00000237654 ENST00000237654	Q14094 [Direct mapping] Cyclin-I A0A024RDH0 [Target identity:100%; Query identity:100%] Cyclin I, isoform CRA_a Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007283 [spermatogenesis] GO:0051726 [regulation of cell cycle] Show all	377 aa 42.6 kDa	No	0
CCNI-002 ENSP00000426235 ENST00000513774	D6RH01 [Direct mapping] Cyclin-I Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0051726 [regulation of cell cycle] Show all	80 aa 9.4 kDa	No	0
CCNI-003 ENSP00000426467 ENST00000505609	D6RG12 [Direct mapping] Cyclin-I Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0051726 [regulation of cell cycle] Show all	125 aa 14.3 kDa	No	0
CCNI-004 ENSP00000421594 ENST00000507788	D6REZ3 [Direct mapping] Cyclin-I Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		49 aa 5.9 kDa	No	0
CCNI-008 ENSP00000425935 ENST00000515468	H0YA27 [Direct mapping] Cyclin-I Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0051726 [regulation of cell cycle] Show all	177 aa 19.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.