Expression of MFSD1 in cancer - Summary - The Human Protein Atlas

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MFSD1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MFSD1
Gene description	Major facilitator superfamily domain containing 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in subsets of immune cells in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA065858
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA065858

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Moderate to strong cytoplasmic positivity was observed in non-Hodkin's lymphomas. Additional weak to moderate cytoplasmic or membranous positivity was observed in a few cancers. Immune cells in tumor stroma were strongly stained.

GENE INFORMATION
Gene name	MFSD1 (HGNC Symbol)
Synonyms	FLJ14153, UG0581B09
Description	Major facilitator superfamily domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q25.32
Chromosome location (bp)	158732198 - 158829719
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118855 (version 83.38)
Entrez gene	64747
UniProt	Q9H3U5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H3U5
Antibodypedia	MFSD1 antibodies

PROTEIN BROWSER

MFSD1-001	MFSD1-008	MFSD1-009	MFSD1-011	MFSD1-012	MFSD1-013	MFSD1-015	MFSD1-018	MFSD1-201	MFSD1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MFSD1-001 ENSP00000403117 ENST00000415822	Q9H3U5 [Direct mapping] Major facilitator superfamily domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	514 aa 56.3 kDa	No	>9
MFSD1-008 ENSP00000419708 ENST00000474670	C9JZW5 [Direct mapping] Major facilitator superfamily domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	161 aa 18.1 kDa	No	2
MFSD1-009 ENSP00000418503 ENST00000482835	C9J5G6 [Direct mapping] Major facilitator superfamily domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	128 aa 14.5 kDa	No	2
MFSD1-011 ENSP00000420699 ENST00000491804	C9JCH3 [Direct mapping] Major facilitator superfamily domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		85 aa 9.3 kDa	No	0
MFSD1-012 ENSP00000418055 ENST00000465739	C9JAC3 [Direct mapping] Major facilitator superfamily domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	37 aa 4.4 kDa	No	1
MFSD1-013 ENSP00000417414 ENST00000486568	C9JBA3 [Direct mapping] Major facilitator superfamily domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	116 aa 13.1 kDa	No	2
MFSD1-015 ENSP00000417163 ENST00000477743	H7C4F4 [Direct mapping] Major facilitator superfamily domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	193 aa 21.1 kDa	No	4
MFSD1-018 ENSP00000264266 ENST00000264266	Q9H3U5 [Direct mapping] Major facilitator superfamily domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	465 aa 51.2 kDa	No	>9
MFSD1-201 ENSP00000376560 ENST00000392813	Q9H3U5 [Direct mapping] Major facilitator superfamily domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	475 aa 51.7 kDa	No	>9
MFSD1-202 ENSP00000484175 ENST00000622669	Q9H3U5 [Direct mapping] Major facilitator superfamily domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	514 aa 56.3 kDa	No	>9

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.