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FGF23

GENERAL INFORMATION

Gene name

 FGF23

Gene description

 Fibroblast growth factor 23

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (AF22)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 FGF23

Synonyms

Description

 Fibroblast growth factor 23 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]

Chromosome

 12

Cytoband

 p13.32

Chromosome location (bp)

 4368227 - 4379728

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118972 (version 83.38)

Entrez gene

 8074

UniProt

 Q9GZV9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9GZV9

Antibodypedia

 FGF23 antibodies

PROTEIN BROWSER
FGF23-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGF23-001
ENSP00000237837
ENST00000237837
Q9GZV9 [Direct mapping]
Fibroblast growth factor 23 Fibroblast growth factor 23 N-terminal peptide Fibroblast growth factor 23 C-terminal peptide
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
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GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005105 [type 1 fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010966 [regulation of phosphate transport]
GO:0010980 [positive regulation of vitamin D 24-hydroxylase activity]
GO:0030500 [regulation of bone mineralization]
GO:0030502 [negative regulation of bone mineralization]
GO:0030643 [cellular phosphate ion homeostasis]
GO:0032026 [response to magnesium ion]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042359 [vitamin D metabolic process]
GO:0042369 [vitamin D catabolic process]
GO:0044320 [cellular response to leptin stimulus]
GO:0045087 [innate immune response]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046888 [negative regulation of hormone secretion]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0055062 [phosphate ion homeostasis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071305 [cellular response to vitamin D]
GO:0071354 [cellular response to interleukin-6]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0090080 [positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway]
GO:1904383 [response to sodium phosphate]
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 251 aa
28 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.